A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution

Freddy Tjosaas; Anne Fiksdahl

doi:10.3390/11020130

A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution

Molecules. 2006 Feb 25;11(2):130-3. doi: 10.3390/11020130.

Authors

Freddy Tjosaas¹, Anne Fiksdahl

Affiliation

¹ Department of Chemistry, Norwegian University of Science and Technology, NTNU N-7491 Trondheim, Norway. tjosas@chem.ntnu.no

Abstract

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.

MeSH terms

Carboxylic Acids / chemical synthesis*
Carboxylic Acids / chemistry
Isonicotinic Acids / chemical synthesis*
Isonicotinic Acids / chemistry
Molecular Structure
Pyridines / chemical synthesis*
Pyridines / chemistry

Substances

Carboxylic Acids
Isonicotinic Acids
Pyridines
methyl 3-fluoropyridine-4-carboxylate