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Page 1
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis.
Bülck C, Nyström EEL, Koudelka T, Mannbar-Frahm M, Andresen G, Radhouani M, Tran F, Scharfenberg F, Schrell F, Armbrust F, Dahlke E, Zhao B, Vervaeke A, Theilig F, Rosenstiel P, Starkl P, Rosshart SP, Fickenscher H, Tholey A, Hansson GC, Becker-Pauly C. Bülck C, et al. Among authors: scharfenberg f. Sci Adv. 2023 Mar 31;9(13):eadf4055. doi: 10.1126/sciadv.adf4055. Epub 2023 Mar 31. Sci Adv. 2023. PMID: 37000885 Free PMC article.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Wichert R, et al. Among authors: scharfenberg f. FASEB J. 2019 Nov;33(11):11925-11940. doi: 10.1096/fj.201801371R. Epub 2019 Aug 9. FASEB J. 2019. PMID: 31381863 Free PMC article.
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C. Scharfenberg F, et al. Cell Mol Life Sci. 2020 Jan;77(2):331-350. doi: 10.1007/s00018-019-03184-4. Epub 2019 Jun 17. Cell Mol Life Sci. 2020. PMID: 31209506
MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.
Werny L, Grogro A, Bickenbach K, Bülck C, Armbrust F, Koudelka T, Pathak K, Scharfenberg F, Sammel M, Sheikhouny F, Tholey A, Linder S, Becker-Pauly C. Werny L, et al. Among authors: scharfenberg f. FEBS J. 2023 Jan;290(1):93-111. doi: 10.1111/febs.16586. Epub 2022 Aug 9. FEBS J. 2023. PMID: 35944080 Free article.
Meprin β: A novel regulator of blood-brain barrier integrity.
Gindorf M, Storck SE, Ohler A, Scharfenberg F, Becker-Pauly C, Pietrzik CU. Gindorf M, et al. Among authors: scharfenberg f. J Cereb Blood Flow Metab. 2021 Jan;41(1):31-44. doi: 10.1177/0271678X20905206. Epub 2020 Feb 16. J Cereb Blood Flow Metab. 2021. PMID: 32065075 Free PMC article.
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
Wünnemann F, Ta-Shma A, Preuss C, Leclerc S, van Vliet PP, Oneglia A, Thibeault M, Nordquist E, Lincoln J, Scharfenberg F, Becker-Pauly C, Hofmann P, Hoff K, Audain E, Kramer HH, Makalowski W, Nir A, Gerety SS, Hurles M, Comes J, Fournier A, Osinska H, Robins J, Pucéat M; MIBAVA Leducq Consortium principal investigators; Elpeleg O, Hitz MP, Andelfinger G. Wünnemann F, et al. Among authors: scharfenberg f. Nat Genet. 2020 Jan;52(1):40-47. doi: 10.1038/s41588-019-0536-2. Epub 2019 Dec 16. Nat Genet. 2020. PMID: 31844321 Free PMC article.
Meprin β and BMP-1 are differentially regulated by CaCl2.
Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P. Schneppenheim J, et al. Among authors: scharfenberg f. Cell Calcium. 2017 Jul;65:8-13. doi: 10.1016/j.ceca.2017.03.005. Epub 2017 Mar 19. Cell Calcium. 2017. PMID: 28365001
16 results