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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Schadt S, Bister B, Chowdhury SK, Funk C, Hop CECA, Humphreys WG, Igarashi F, James AD, Kagan M, Khojasteh SC, Nedderman ANR, Prakash C, Runge F, Scheible H, Spracklin DK, Swart P, Tse S, Yuan J, Obach RS. Schadt S, et al. Among authors: runge f. Drug Metab Dispos. 2018 Jun;46(6):865-878. doi: 10.1124/dmd.117.079848. Epub 2018 Feb 27. Drug Metab Dispos. 2018. PMID: 29487142 Review.
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein-Ligand Interactions at High Throughput.
Simon RP, Winter M, Kleiner C, Wehrle L, Karnath M, Ries R, Zeeb M, Schnapp G, Fiegen D, Häbe TT, Runge F, Bretschneider T, Luippold AH, Bischoff D, Reindl W, Büttner FH. Simon RP, et al. Among authors: runge f. SLAS Discov. 2021 Jan;26(1):44-57. doi: 10.1177/2472555220959266. Epub 2020 Oct 17. SLAS Discov. 2021. PMID: 33073664 Free article.
Genotoxicity Assessment of Drug Metabolites in the Context of MIST and Beyond.
Zeller A, Brigo A, Brink A, Guerard M, Lang D, Muster W, Runge F, Sutter A, Vock E, Wichard J, Schadt S. Zeller A, et al. Among authors: runge f. Chem Res Toxicol. 2020 Jan 21;33(1):10-19. doi: 10.1021/acs.chemrestox.9b00348. Epub 2020 Jan 9. Chem Res Toxicol. 2020. PMID: 31859487
18 results