Frank Totzke - Search Results

Year	Number of Results
2005	3
2006	4
2007	3
2008	6
2009	7
2010	5
2011	7
2012	7
2013	3
2014	6
2015	2
2016	2
2017	4
2018	4
2021	1
2024	0

1

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach.

Tell V, Hilbrich I, Holzer M, Totzke F, Schachtele C, Slynko I, Sippl W, Hilgeroth A. Tell V, et al. Among authors: totzke f. Curr Alzheimer Res. 2016;13(12):1330-1336. doi: 10.2174/1567205013666160615091821. Curr Alzheimer Res. 2016. PMID: 27306698 Review.

2

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.

Karatas M, Chaikuad A, Berger B, Kubbutat MHG, Totzke F, Knapp S, Kunick C. Karatas M, et al. Among authors: totzke f. Molecules. 2021 Mar 14;26(6):1611. doi: 10.3390/molecules26061611. Molecules. 2021. PMID: 33799460 Free PMC article.

3

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.

Schlütke L, Immer M, Preu L, Totzke F, Schächtele C, Kubbutat MHG, Kunick C. Schlütke L, et al. Among authors: totzke f. Eur J Pharm Biopharm. 2018 May;126:89-94. doi: 10.1016/j.ejpb.2017.03.011. Epub 2017 Mar 15. Eur J Pharm Biopharm. 2018. PMID: 28315448

4

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA. Freitag A, et al. Among authors: totzke f. J Med Chem. 2015 Jan 8;58(1):212-21. doi: 10.1021/jm5006034. Epub 2014 Jul 14. J Med Chem. 2015. PMID: 24983663

5

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R.

Hempel C, Totzke F, Schächtele C, Najjar A, Sippl W, Ritter C, Hilgeroth A. Hempel C, et al. Among authors: totzke f. J Enzyme Inhib Med Chem. 2017 Dec;32(1):271-276. doi: 10.1080/14756366.2016.1247062. J Enzyme Inhib Med Chem. 2017. PMID: 28097905 Free PMC article.

6

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri.

Hamed ANE, Schmitz R, Bergermann A, Totzke F, Kubbutat M, Müller WEG, Youssef DTA, Bishr MM, Kamel MS, Edrada-Ebel R, Wätjen W, Proksch P. Hamed ANE, et al. Among authors: totzke f. Z Naturforsch C J Biosci. 2018 Apr 25;73(5-6):199-210. doi: 10.1515/znc-2017-0161. Z Naturforsch C J Biosci. 2018. PMID: 29353267 Free article.

7

Roscovitine targets, protein kinases and pyridoxal kinase.

Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, Koken M, Coburn SP, Tang L, Jiang T, Liang DC, Galons H, Dierick JF, Pinna LA, Meggio F, Totzke F, Schächtele C, Lerman AS, Carnero A, Wan Y, Gray N, Meijer L. Bach S, et al. Among authors: totzke f. J Biol Chem. 2005 Sep 2;280(35):31208-19. doi: 10.1074/jbc.M500806200. Epub 2005 Jun 23. J Biol Chem. 2005. PMID: 15975926 Free article.

8

Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.

Fischer T, Krüger T, Najjar A, Totzke F, Schächtele C, Sippl W, Ritter C, Hilgeroth A. Fischer T, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. doi: 10.1016/j.bmcl.2017.04.053. Epub 2017 Apr 19. Bioorg Med Chem Lett. 2017. PMID: 28478927

9

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Determann R, et al. Among authors: totzke f. Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14. Eur J Med Chem. 2012. PMID: 22560627

10

Discovery of 4-anilino α-carbolines as novel Brk inhibitors.

Mahmoud KA, Krug M, Wersig T, Slynko I, Schächtele C, Totzke F, Sippl W, Hilgeroth A. Mahmoud KA, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51. doi: 10.1016/j.bmcl.2014.03.002. Epub 2014 Mar 12. Bioorg Med Chem Lett. 2014. PMID: 24650640

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