Synthesis of gamma-nitro aliphatic methyl esters via Michael additions promoted by microwave irradiation

Molecules. 2009 Apr 21;14(4):1595-604. doi: 10.3390/molecules14041595.

Abstract

A simple and efficient protocol has been developed for the direct synthesis of gamma-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Butyrates / chemical synthesis
  • Butyrates / chemistry
  • Combinatorial Chemistry Techniques / methods*
  • Esters* / chemical synthesis
  • Esters* / chemistry
  • Microwaves*
  • Molecular Structure

Substances

  • Butyrates
  • Esters