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IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. Schmacke NA, et al. Among authors: pinci f. Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Immunity. 2022. PMID: 36384135 Free PMC article.
Tumor necrosis factor is a necroptosis-associated alarmin.
Pinci F, Gaidt MM, Jung C, Nagl D, Kuut G, Hornung V. Pinci F, et al. Front Immunol. 2022 Dec 12;13:1074440. doi: 10.3389/fimmu.2022.1074440. eCollection 2022. Front Immunol. 2022. PMID: 36578489 Free PMC article.
C-tag TNF: a reporter system to study TNF shedding.
Pinci F, Gaidt MM, Jung C, Kuut G, Jackson MA, Bauernfried S, Hornung V. Pinci F, et al. J Biol Chem. 2020 Dec 25;295(52):18065-18075. doi: 10.1074/jbc.RA120.015248. Epub 2020 Oct 20. J Biol Chem. 2020. PMID: 33082141 Free PMC article.