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Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Ozyerli-Goknar E, Kala EY, Aksu AC, Bulut I, Cingöz A, Nizamuddin S, Biniossek M, Seker-Polat F, Morova T, Aztekin C, Kung SHY, Syed H, Tuncbag N, Gönen M, Philpott M, Cribbs AP, Acilan C, Lack NA, Onder TT, Timmers HTM, Bagci-Onder T. Ozyerli-Goknar E, et al. Among authors: seker polat f. Cell Commun Signal. 2023 Nov 16;21(1):328. doi: 10.1186/s12964-023-01335-6. Cell Commun Signal. 2023. PMID: 37974198 Free PMC article.
Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.
Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Wei JJ, Bulun S, Yue F, Adli M. Buyukcelebi K, et al. Among authors: seker polat f. Res Sq [Preprint]. 2023 Feb 9:rs.3.rs-2537075. doi: 10.21203/rs.3.rs-2537075/v1. Res Sq. 2023. PMID: 36798375 Free PMC article. Updated. Preprint.
Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism.
Pujadas EM, Wei X, Acosta N, Carter L, Yang J, Almassalha L, Daneshkhah A, Rao SSP, Agrawal V, Seker-Polat F, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas EM, et al. Among authors: seker polat f. bioRxiv [Preprint]. 2023 Jun 26:2023.06.26.546573. doi: 10.1101/2023.06.26.546573. bioRxiv. 2023. PMID: 37425796 Free PMC article. Updated. Preprint.
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism.
Pujadas Liwag EM, Wei X, Acosta N, Carter LM, Yang J, Almassalha LM, Jain S, Daneshkhah A, Rao SSP, Seker-Polat F, MacQuarrie KL, Ibarra J, Agrawal V, Aiden EL, Kanemaki MT, Backman V, Adli M. Pujadas Liwag EM, et al. Among authors: seker polat f. Genome Biol. 2024 Mar 22;25(1):77. doi: 10.1186/s13059-024-03212-y. Genome Biol. 2024. PMID: 38519987 Free PMC article.