Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation.
Globisch MA, Onyeogaziri FC, Jauhiainen S, Yau ACY, Orsenigo F, Conze LL, Arce M, Corada M, Smith RO, Rorsman C, Sundell V, Fernando D, Daniel G, Mattsson O, Savander H, Wanders A, Rezai Jahromi B, Laakso A, Niemelä M, Dejana E, Magnusson PU.
Globisch MA, et al.
Blood. 2022 Nov 17;140(20):2154-2169. doi: 10.1182/blood.2021015350.
Blood. 2022.
PMID: 35981497
Free PMC article.
We found that Ccm3-deficient brain endothelial cells had a higher expression of genes related to the coagulation cascade and hypoxia when compared with wild-type brain endothelial cells. ...With transcriptomics, comprehensive imaging, and an in vitro CCM preclinical model, …
We found that Ccm3-deficient brain endothelial cells had a higher expression of genes related to the coagulation cascade and hypoxia …