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H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.
Haase S, Banerjee K, Mujeeb AA, Hartlage CS, Núñez FM, Núñez FJ, Alghamri MS, Kadiyala P, Carney S, Barissi MN, Taher AW, Brumley EK, Thompson S, Dreyer JT, Alindogan CT, Garcia-Fabiani MB, Comba A, Venneti S, Ravikumar V, Koschmann C, Carcaboso ÁM, Vinci M, Rao A, Yu JS, Lowenstein PR, Castro MG. Haase S, et al. Among authors: nunez fm. J Clin Invest. 2022 Nov 15;132(22):e154229. doi: 10.1172/JCI154229. J Clin Invest. 2022. PMID: 36125896 Free PMC article.
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice.
Kadiyala P, Carney SV, Gauss JC, Garcia-Fabiani MB, Haase S, Alghamri MS, Núñez FJ, Liu Y, Yu M, Taher A, Nunez FM, Li D, Edwards MB, Kleer CG, Appelman H, Sun Y, Zhao L, Moon JJ, Schwendeman A, Lowenstein PR, Castro MG. Kadiyala P, et al. Among authors: nunez fm. J Clin Invest. 2021 Feb 15;131(4):e139542. doi: 10.1172/JCI139542. J Clin Invest. 2021. PMID: 33332283 Free PMC article.
Prospects of biological and synthetic pharmacotherapies for glioblastoma.
Altshuler DB, Kadiyala P, Nuñez FJ, Nuñez FM, Carney S, Alghamri MS, Garcia-Fabiani MB, Asad AS, Nicola Candia AJ, Candolfi M, Lahann J, Moon JJ, Schwendeman A, Lowenstein PR, Castro MG. Altshuler DB, et al. Among authors: nunez fm. Expert Opin Biol Ther. 2020 Mar;20(3):305-317. doi: 10.1080/14712598.2020.1713085. Epub 2020 Jan 20. Expert Opin Biol Ther. 2020. PMID: 31959027 Free PMC article. Review.
H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas.
Garcia-Fabiani MB, Haase S, Banerjee K, McClellan B, Zhu Z, Mujeeb A, Li Y, Yu J, Kadiyala P, Taher A, Núñez FJ, Alghamri MS, Comba A, Mendez FM, Nicola Candia AJ, Salazar B, Koschmann C, Nunez FM, Edwards M, Qin T, Sartor MA, Lowenstein PR, Castro MG. Garcia-Fabiani MB, et al. Among authors: nunez fm. bioRxiv [Preprint]. 2023 Jun 13:2023.06.13.544658. doi: 10.1101/2023.06.13.544658. bioRxiv. 2023. PMID: 37398299 Free PMC article. Preprint.
Genetically Engineered Mouse Model of Brainstem High-Grade Glioma.
Nunez FM, Gauss JC, Mendez FM, Haase S, Lowenstein PR, Castro MG. Nunez FM, et al. STAR Protoc. 2020 Nov 25;1(3):100165. doi: 10.1016/j.xpro.2020.100165. eCollection 2020 Dec 18. STAR Protoc. 2020. PMID: 33377059 Free PMC article.
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Mendez F, Kadiyala P, Nunez FJ, Carney S, Nunez FM, Gauss JC, Ravindran R, Pawar S, Edwards M, Garcia-Fabiani MB, Haase S, Lowenstein PR, Castro MG. Mendez F, et al. Among authors: nunez fm. Clin Cancer Res. 2020 Aug 1;26(15):4080-4092. doi: 10.1158/1078-0432.CCR-19-3714. Epub 2020 Apr 24. Clin Cancer Res. 2020. PMID: 32332014 Free PMC article.