Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids.
Murillo JA, Gil JF, Upegui YA, Restrepo AM, Robledo SM, Quiñones W, Echeverri F, San Martin A, Olivo HF, Escobar G.
Murillo JA, et al. Among authors: echeverri f.
Bioorg Med Chem. 2019 Jan 1;27(1):153-160. doi: 10.1016/j.bmc.2018.11.030. Epub 2018 Nov 22.
Bioorg Med Chem. 2019.
PMID: 30482546
Beyerenols 1 and 2 showed EC(50) of 4.6 9.4 and 5.3 9.4 mug/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, respectively. Beyerenol 1 was synthesized from stevioside. In vivo experiments with bereyenols showed cure in 50% of hamsters infected with …
Beyerenols 1 and 2 showed EC(50) of 4.6 9.4 and 5.3 9.4 mug/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, res …