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Page 1
Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids.
Murillo JA, Gil JF, Upegui YA, Restrepo AM, Robledo SM, Quiñones W, Echeverri F, San Martin A, Olivo HF, Escobar G. Murillo JA, et al. Among authors: echeverri f. Bioorg Med Chem. 2019 Jan 1;27(1):153-160. doi: 10.1016/j.bmc.2018.11.030. Epub 2018 Nov 22. Bioorg Med Chem. 2019. PMID: 30482546
Beyerenols 1 and 2 showed EC(50) of 4.6 9.4 and 5.3 9.4 mug/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, respectively. Beyerenol 1 was synthesized from stevioside. In vivo experiments with bereyenols showed cure in 50% of hamsters infected with …
Beyerenols 1 and 2 showed EC(50) of 4.6 9.4 and 5.3 9.4 mug/mL against amastigotes of L. (V) brazilensis, with SI of 5.1 and 7.7, res …
Effect of substituents in the A and B rings of chalcones on antiparasite activity.
González LA, Upegui YA, Rivas L, Echeverri F, Escobar G, Robledo SM, Quiñones W. González LA, et al. Among authors: echeverri f. Arch Pharm (Weinheim). 2020 Dec;353(12):e2000157. doi: 10.1002/ardp.202000157. Epub 2020 Aug 17. Arch Pharm (Weinheim). 2020. PMID: 33252148
Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity against Leishmania braziliensis, Trypanosoma cruzi, and Plasmodium falciparum. The compounds were active against L. braziliensis in a stru …
Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity again …
Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process.
Upegui Zapata YA, Echeverri F, Quiñones W, Torres F, Nacher M, Rivas LI, Meira CDS, Gedamu L, Escobar G, Archbold R, Vélez ID, Robledo SM. Upegui Zapata YA, et al. Among authors: echeverri f. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:94-106. doi: 10.1016/j.ijpddr.2020.06.004. Epub 2020 Jun 26. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32734890 Free PMC article.
Here, we evaluated the in vitro effectiveness of hydrazone derived from chromanes 2-(2,3-dihydro-4H-1-benzothiopyran-4-ylidene) hydrazide (TC1) and 2-(2,3-dihydro-4H-1-benzopyran-4-ylidene) hydrazide (TC2) and the mixture of triterpene saponin hederagenin-3-O-(3,4-O-diacetyl-ss-D …
Here, we evaluated the in vitro effectiveness of hydrazone derived from chromanes 2-(2,3-dihydro-4H-1-benzothiopyran-4-ylidene) hydrazide (T …
Biological activities of 4H-thiochromen-4-one 1,1-dioxide derivatives against tropical disease parasites: A target-based drug design approach.
Ortiz C, Breuning M, Robledo S, Echeverri F, Vargas E, Quiñones W. Ortiz C, et al. Among authors: echeverri f. Heliyon. 2023 Jul 1;9(7):e17801. doi: 10.1016/j.heliyon.2023.e17801. eCollection 2023 Jul. Heliyon. 2023. PMID: 37483711 Free PMC article.
Previous studies have established that an isosteric replacement of naphthoquinone's carbonyl group with a sulfone group leads to compounds with high bioactivity and selectivity (half-maximal inhibitory concentration = 3 muM against intracellular amastigotes of L. panamensi …
Previous studies have established that an isosteric replacement of naphthoquinone's carbonyl group with a sulfone group leads to compounds w …
Increased accumulation of isoflavonoids in common bean (Phaseolus vulgaris L.) tissues treated with 1-oxo-indane-4-carboxylic acid derivatives.
Botero L, Vizcaíno S, Quiñones W, Echeverri F, Gil J, Durango D. Botero L, et al. Among authors: echeverri f. Biotechnol Rep (Amst). 2021 Feb 23;29:e00601. doi: 10.1016/j.btre.2021.e00601. eCollection 2021 Mar. Biotechnol Rep (Amst). 2021. PMID: 33732630 Free PMC article.
Isoflavonoid phytoalexins (isoflavones: genistein, 2'-hydroxygenistein, and daidzein; isoflavanones: dalbergioidin and kievitone; coumestrol; pterocarpans: phaseollidin and phaseollin; and the isoflavan: phaseollinisoflavan) production in response to the application of eleven 1-o …
Isoflavonoid phytoalexins (isoflavones: genistein, 2'-hydroxygenistein, and daidzein; isoflavanones: dalbergioidin and kievitone; coumestrol …
Exploring Antiparasitic Molecule Sources from Timber by-Product Industries-Leishmanicidal and Trypanocidal Compounds from Clathrotropis brunnea Amshoff.
Torres F, Robledo SM, Quiñones W, Escobar G, Archbold R, Correa E, Gil JF, Arbeláez N, Murillo J, Echeverri F. Torres F, et al. Among authors: echeverri f. Front Pharmacol. 2020 Dec 24;11:584668. doi: 10.3389/fphar.2020.584668. eCollection 2020. Front Pharmacol. 2020. PMID: 33424593 Free PMC article.
The effectiveness of the two metabolites was confirmed in a hamster model of cutaneous Leishmaniasis by Leishmania braziliensis and in Balb/c mice infected by Trypanosoma cruzi. In vitro, 3,5-dimethoxystilbene was the most active against L. braziliensis amastigotes, with a …
The effectiveness of the two metabolites was confirmed in a hamster model of cutaneous Leishmaniasis by Leishmania braziliensis and in Balb/ …
Evaluation of the hypoglycemic effects of flavonoids and extracts from Jatropha gossypifolia L.
Granados S, Balcázar N, Guillén A, Echeverri F. Granados S, et al. Among authors: echeverri f. Molecules. 2015 Apr 9;20(4):6181-93. doi: 10.3390/molecules20046181. Molecules. 2015. PMID: 25859777 Free PMC article.
Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. ...This compound retains the previously reported activity, stimulating in vitro t …
Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are fe …
O-Methylation of phenylphenalenone phytoalexins in Musaacuminata and Wachendorfia thyrsiflora.
Otálvaro F, Jitsaeng K, Munde T, Echeverri F, Quiñones W, Schneider B. Otálvaro F, et al. Among authors: echeverri f. Phytochemistry. 2010 Feb;71(2-3):206-13. doi: 10.1016/j.phytochem.2009.10.019. Epub 2009 Nov 24. Phytochemistry. 2010. PMID: 19939423
The inducibility of O-methylated metabolites was demonstrated in both species and the origin of methoxyl group from [methyl-13C]L-methionine was confirmed. In addition to known phenylphenalenones, a methoxylated metabolite, 4-(4-hydroxy-3-methoxy-phenyl)-benzo[de]isochrome …
The inducibility of O-methylated metabolites was demonstrated in both species and the origin of methoxyl group from [methyl-13C]L-met …
Preparation of rotenone derivatives and in vitro analysis of their antimalarial, antileishmanial and selective cytotoxic activities.
Upegui Y, Gil JF, Quiñones W, Torres F, Escobar G, Robledo SM, Echeverri F. Upegui Y, et al. Among authors: echeverri f. Molecules. 2014 Nov 18;19(11):18911-22. doi: 10.3390/molecules191118911. Molecules. 2014. PMID: 25412039 Free PMC article.
Rotenone had an EC50 of 19.0 M against P. falciparum, and 127.2 M against L. panamensis. Although chemical transformation does not improve its biological profile against P. falciparum, three of its derivatives showed a significant level of action within an adequate range o …
Rotenone had an EC50 of 19.0 M against P. falciparum, and 127.2 M against L. panamensis. Although chemical transformation does not im …
12 results