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Life style and Parkinson's disease.
Reichmann H, Csoti I, Koschel J, Lorenzl S, Schrader C, Winkler J, Wüllner U. Reichmann H, et al. J Neural Transm (Vienna). 2022 Sep;129(9):1235-1245. doi: 10.1007/s00702-022-02509-1. Epub 2022 May 23. J Neural Transm (Vienna). 2022. PMID: 35606622 Free PMC article. Review.
We present here comprehensive information on the influence of the environment, diet (especially caffeine, nicotine, alcohol, chocolate and dairy products), physical activity and sleep on risk and course of Parkinson's disease....
We present here comprehensive information on the influence of the environment, diet (especially caffeine, nicotine, alcohol, chocolat …
[Nutritional aspects in Parkinson's disease: disease risk, dietary therapy and treatment of digestive tract dysfunction].
Csoti I, Dresel C, Hauptmann B, Müller T, Redecker C, Warnecke T, Wüllner U. Csoti I, et al. Fortschr Neurol Psychiatr. 2018 Sep;86(S 01):S34-S42. doi: 10.1055/a-0681-6700. Epub 2018 Sep 21. Fortschr Neurol Psychiatr. 2018. PMID: 30241099 Review. German.
Also, a number of studies revaeled positive effects on disease progression by caffeine, higher uric acid and total cholesterol levels - especially in men. ...
Also, a number of studies revaeled positive effects on disease progression by caffeine, higher uric acid and total cholesterol levels …
Molecular recognition of caffeine in solution and solid state.
Sahoo P. Sahoo P. Bioorg Chem. 2015 Feb;58:26-47. doi: 10.1016/j.bioorg.2014.11.002. Epub 2014 Nov 15. Bioorg Chem. 2015. PMID: 25462624 Review.
In this contribution, it has been illustrated the immense variety of receptors that have been designed for caffeine recognition in both solid and solution phase. The binding studies for the recognition of caffeine are reported by different research groups including …
In this contribution, it has been illustrated the immense variety of receptors that have been designed for caffeine recognition in bo …
Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine.
Senekowitsch S, Foja C, Wildgrube T, Schick P, Rosenbaum C, Krause J, Brokmann F, Kromrey ML, Engeli S, Weitschies W, Grimm M. Senekowitsch S, et al. Pharmaceutics. 2023 Mar 22;15(3):1012. doi: 10.3390/pharmaceutics15031012. Pharmaceutics. 2023. PMID: 36986872 Free PMC article.
For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of t …
For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were develo …
Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics.
Tzakri T, Rehenbrock L, Senekowitsch S, Rump A, Schick P, Krause J, Kromrey ML, Grimm M, Weitschies W. Tzakri T, et al. Pharmaceutics. 2023 Nov 4;15(11):2584. doi: 10.3390/pharmaceutics15112584. Pharmaceutics. 2023. PMID: 38004563 Free PMC article.
The two dosage forms were administered simultaneously to 12 volunteers in an upright position under fasted and fed state conditions. To distinguish the caffeine concentrations in saliva from each dosage form, regular type of caffeine ((12)C) was added to the tablet, …
The two dosage forms were administered simultaneously to 12 volunteers in an upright position under fasted and fed state conditions. To dist …
Comparing the gastric emptying of 240 mL and 20 mL water by MRI and caffeine salivary tracer technique.
Grimm M, Aude P, Feldmüller M, Keßler R, Scheuch E, Tzvetkov MV, Koziolek M, Weitschies W. Grimm M, et al. Eur J Pharm Biopharm. 2023 Mar;184:150-158. doi: 10.1016/j.ejpb.2023.01.021. Epub 2023 Feb 1. Eur J Pharm Biopharm. 2023. PMID: 36736963
Only slighter slower emptying after intake of 20 mL was observed. Salivary caffeine pharmacokinetics representing mass transfer from stomach to small intestine after intake of different volumes did not differ. ...Relative gastric emptying as measured with MRI and salivary …
Only slighter slower emptying after intake of 20 mL was observed. Salivary caffeine pharmacokinetics representing mass transfer from …
Combined Application of MRI and the Salivary Tracer Technique to Determine the in Vivo Disintegration Time of Immediate Release Formulation Administered to Healthy, Fasted Subjects.
Sager M, Grimm M, Jedamzik P, Merdivan S, Kromrey ML, Hasan M, Koziolek M, Tzvetkov MV, Weitschies W. Sager M, et al. Mol Pharm. 2019 Apr 1;16(4):1782-1786. doi: 10.1021/acs.molpharmaceut.8b01320. Epub 2019 Mar 8. Mol Pharm. 2019. PMID: 30821987
After an overnight fast of at least 10 h and caffeine abstinence of minimum 72 h, conventional hard gelatin capsules containing 50 mg caffeine and 5 mg iron oxide were administered to 8 healthy volunteers. ...This delay could be explained by the fact that the appear …
After an overnight fast of at least 10 h and caffeine abstinence of minimum 72 h, conventional hard gelatin capsules containing 50 mg …
In vivo characterization of enTRinsic™ drug delivery technology capsule after intake in fed state: A cross-validation approach using salivary tracer technique in comparison to MRI.
Sager M, Grimm M, Aude P, Schick P, Merdivan S, Hasan M, Kromrey ML, Sivert A, Benameur H, Koziolek M, Tzvetkov MV, Weitschies W. Sager M, et al. J Control Release. 2019 Nov 10;313:24-32. doi: 10.1016/j.jconrel.2019.10.023. Epub 2019 Oct 15. J Control Release. 2019. PMID: 31626859 Clinical Trial.
Saliva samples were obtained simultaneously with MR imaging. Caffeine concentrations in saliva were determined by LC/MS-MS. The starting point of capsule disintegration was determined visually by inspection of the MR images as well as by the onset of salivary caffeine …
Saliva samples were obtained simultaneously with MR imaging. Caffeine concentrations in saliva were determined by LC/MS-MS. The start …
Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study.
Sager M, Jedamzik P, Merdivan S, Grimm M, Schneider F, Kromrey ML, Hasan M, Oswald S, Kühn J, Koziolek M, Weitschies W. Sager M, et al. Eur J Pharm Biopharm. 2018 Jun;127:443-452. doi: 10.1016/j.ejpb.2018.03.011. Epub 2018 Mar 27. Eur J Pharm Biopharm. 2018. PMID: 29602018
The aim of this study was to develop an in vivo tool to determine gastric emptying of water by administration of a caffeine as a tracer substance followed by subsequent saliva caffeine analysis. ...Caffeine was administered in form of an ice capsule in order …
The aim of this study was to develop an in vivo tool to determine gastric emptying of water by administration of a caffeine as a trac …