Detection and photothermal inactivation of Gram-positive and Gram-negative bloodstream bacteria using photonic crystal biosensor and plasmonic core-shell

Ruth Birhanu Hayilesilassie; Abebe Belay Gemta; Fekadu Tolessa Maremi; Alemayehu Getahun Kumela; Kusse Gudishe; Bereket Delga Dana

doi:10.1039/d4ra01802h

Detection and photothermal inactivation of Gram-positive and Gram-negative bloodstream bacteria using photonic crystal biosensor and plasmonic core-shell

RSC Adv. 2024 Apr 10;14(16):11594-11603. doi: 10.1039/d4ra01802h. eCollection 2024 Apr 3.

Authors

Ruth Birhanu Hayilesilassie¹, Abebe Belay Gemta¹, Fekadu Tolessa Maremi¹, Alemayehu Getahun Kumela², Kusse Gudishe³, Bereket Delga Dana³

Affiliations

¹ Department of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University P.O.Box 1888 Adama Ethiopia abebebelay96@gmail.com butaabush@gmail.com.
² Department of Applied Physics, College of Natural and Computational Sciences, Mekdela Amba University P.O.Box 032 Tullu Awulia Ethiopia.
³ Department of Applied Physics, College of Natural and Computational Sciences, Jinka University Jinka Ethiopia.

Abstract

Plasmonics and core-shell nanomaterials hold great potential to develop pharmaceuticals and medical equipment due to their eco-friendly and cost effective fabrication procedures. Despite these advancements, combating drug-resistant bacterial infections remains a global challenge. Therefore, this study aims to introduce a tailored theoretical framework for a one-dimensional (1D) photonic crystal biosensor (PCB) composed of (ZrO₂/GaN)^N/defect layer/(ZrO₂/GaN)^N, designed to detect Gram-positive and Gram-negative bloodstream bacteria employing the transfer matrix method (TMM). In addition, using the finite difference methods (FDM), the photothermal inactivation of bloodstream bacteria with plasmonic core-shell structures (FeO@AuBiS₂) was explored using key factors such as light absorption, heat generation, and thermal diffusion. By incorporating six dielectric layers and contaminated blood into the proposed PCB, a maximum sensitivity of 562 nm per RIU was recorded, and using rod-shaped plasmonic core-shell structures, 5.8 nm^-1 light absorption capacity and 152 K change in temperature were achieved. The maximum detection sensitivity, light absorption, heat conduction and heat convection capacity of the proposed 1D PCB and plasmonic core-shell show an effective approach to combating drug-resistant bacteria.