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Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines.
Cerchia C, Nasso R, Mori M, Villa S, Gelain A, Capasso A, Aliotta F, Simonetti M, Rullo R, Masullo M, De Vendittis E, Ruocco MR, Lavecchia A. Cerchia C, et al. Among authors: aliotta f. J Med Chem. 2019 Aug 8;62(15):7089-7110. doi: 10.1021/acs.jmedchem.9b00632. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31294975
Development of a Stromal Microenvironment Experimental Model Containing Proto-Myofibroblast Like Cells and Analysis of Its Crosstalk with Melanoma Cells: A New Tool to Potentiate and Stabilize Tumor Suppressor Phenotype of Dermal Myofibroblasts.
Avagliano A, Ruocco MR, Nasso R, Aliotta F, Sanità G, Iaccarino A, Bellevicine C, Calì G, Fiume G, Masone S, Masullo M, Montagnani S, Arcucci A. Avagliano A, et al. Among authors: aliotta f. Cells. 2019 Nov 14;8(11):1435. doi: 10.3390/cells8111435. Cells. 2019. PMID: 31739477 Free PMC article.
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.
Aliotta F, Nasso R, Rullo R, Arcucci A, Avagliano A, Simonetti M, Sanità G, Masullo M, Lavecchia A, Ruocco MR, Vendittis E. Aliotta F, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1866-1878. doi: 10.1080/14756366.2020.1819257. J Enzyme Inhib Med Chem. 2020. PMID: 32990107 Free PMC article.