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Showing results for fenglin ao
Your search for Fanglin Ao retrieved no results
Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors.
Xiao Z, Chu C, Zhou L, Zhou Z, Zhang Q, Yang F, Yang Z, Zheng P, Xu S, Zhu W. Xiao Z, et al. Bioorg Med Chem. 2020 Oct 1;28(19):115669. doi: 10.1016/j.bmc.2020.115669. Epub 2020 Jul 28. Bioorg Med Chem. 2020. PMID: 32912435
The most promising compound 13a exhibited the similar IC(50) values on A549 and H1975 cell lines to the lead drug Olmutinib, and exhibited excellent activity and selectivity on EGFR(T790M/L858R) in the kinase experiment. AO and Hoechst33258 staining indicated that 13a coul …
The most promising compound 13a exhibited the similar IC(50) values on A549 and H1975 cell lines to the lead drug Olmutinib, and exhibited e …
A Novel Dual PI3K/mTOR Inhibitor, XIN-10, for the Treatment of Cancer.
Luo L, Sun X, Yang Y, Xia L, Wang S, Fu Y, Zhu Y, Xu S, Zhu W. Luo L, et al. Int J Mol Sci. 2023 Oct 1;24(19):14821. doi: 10.3390/ijms241914821. Int J Mol Sci. 2023. PMID: 37834269 Free PMC article.
We screened three cell lines for more in-depth exploration by MTT experiments. From the AO staining, cell cycle and apoptosis, we found that XIN-10 had a more obvious inhibitory effect on the MCF-7 breast cancer cell line and used this as a selection for more in-depth expe …
We screened three cell lines for more in-depth exploration by MTT experiments. From the AO staining, cell cycle and apoptosis, we fou …
Discovery of novel 4-arylamino-quinazoline derivatives as EGFRL858R/T790M inhibitors with the potential to inhibit the non-small cell lung cancers.
Gan W, Wang C, Pan Q, Li Y, Guo Y, Fan D, Peng Y, Rao Z, Xu S, Zheng P, Zhu W. Gan W, et al. Bioorg Chem. 2022 Oct;127:105994. doi: 10.1016/j.bioorg.2022.105994. Epub 2022 Jun 30. Bioorg Chem. 2022. PMID: 35792314
What's more, they also showed moderate to excellent kinase inhibitory activity against EGFR(WT) and EGFR(L858R/T790M). 8o exhibited the best kinase inhibitory activity with IC(50) values of 0.8, 2.7 nM against EGFR(WT) and EGFR(L858R/T790M), respectively. Moreover, AO sing …
What's more, they also showed moderate to excellent kinase inhibitory activity against EGFR(WT) and EGFR(L858R/T790M). 8o exhibited the best …
Discovery of Triazolo-pyridazine/-pyrimidine Derivatives Bearing Aromatic (Heterocycle)-Coupled Azole Units as Class II c-Met Inhibitors.
Zhang Q, Liu X, Gan W, Wu J, Zhou H, Yang Z, Zhang Y, Liao M, Yuan P, Xu S, Zheng P, Zhu W. Zhang Q, et al. ACS Omega. 2020 Jun 29;5(27):16482-16490. doi: 10.1021/acsomega.0c00838. eCollection 2020 Jul 14. ACS Omega. 2020. PMID: 32685812 Free PMC article.
Moreover, the inhibitory activity of compound 12e against c-Met kinase (IC(50) = 0.090 muM) was equal to that of Foretinib (IC(50) = 0.019 muM). The result of the acridine orange (AO) single staining test demonstrated that compound 12e could remarkably induce apoptosis of …
Moreover, the inhibitory activity of compound 12e against c-Met kinase (IC(50) = 0.090 muM) was equal to that of Foretinib (IC(50) = 0.019 m …
Computer-assisted preoperative planning improves the learning curve of PFNA-II in the treatment of intertrochanteric femoral fractures.
Wang D, Zhang K, Qiang M, Jia X, Chen Y. Wang D, et al. BMC Musculoskelet Disord. 2020 Jan 16;21(1):34. doi: 10.1186/s12891-020-3048-4. BMC Musculoskelet Disord. 2020. PMID: 31948409 Free PMC article.

Significant differences were observed between group A and B in Harris score at last follow-up in the AO/OTA type 31-A2 intertrochanteric fracture (P < 0.05). CONCLUSION: Compared with conventional preoperative planning methods, CAPP system significantly reduced operatio

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Significant differences were observed between group A and B in Harris score at last follow-up in the AO/OTA type 31-A2 intertrochante …
11 results