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Page 1
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants.
Huang C, Shuai H, Qiao J, Hou Y, Zeng R, Xia A, Xie L, Fang Z, Li Y, Yoon C, Huang Q, Hu B, You J, Quan B, Zhao X, Guo N, Zhang S, Ma R, Zhang J, Wang Y, Yang R, Zhang S, Nan J, Xu H, Wang F, Lei J, Chu H, Yang S. Huang C, et al. Among authors: wang f. Signal Transduct Target Ther. 2023 Mar 16;8(1):128. doi: 10.1038/s41392-023-01392-w. Signal Transduct Target Ther. 2023. PMID: 36928316 Free PMC article.
Asymmetric Total Syntheses of Kopsia Indole Alkaloids.
Leng L, Zhou X, Liao Q, Wang F, Song H, Zhang D, Liu XY, Qin Y. Leng L, et al. Among authors: wang f. Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3703-3707. doi: 10.1002/anie.201700831. Epub 2017 Feb 23. Angew Chem Int Ed Engl. 2017. PMID: 28230294
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Quan BX, Shuai H, Xia AJ, Hou Y, Zeng R, Liu XL, Lin GF, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF, Lei J, Chu H, Yang S. Quan BX, et al. Nat Microbiol. 2022 May;7(5):716-725. doi: 10.1038/s41564-022-01119-7. Epub 2022 Apr 27. Nat Microbiol. 2022. PMID: 35477751
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants.
Pan S, Zhang L, Luo X, Nan J, Yang W, Bin H, Li Y, Huang Q, Wang T, Pan Z, Mu B, Wang F, Tian C, Liu Y, Li L, Yang S. Pan S, et al. Among authors: wang f. J Med Chem. 2022 Feb 10;65(3):2035-2058. doi: 10.1021/acs.jmedchem.1c01597. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080890