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1991 2
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Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.
Wu F, Li X, Looso M, Liu H, Ding D, Günther S, Kuenne C, Liu S, Weissmann N, Boettger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gärtner U, Potente M, Zhou Y, Yuan X, Braun T. Wu F, et al. Nat Genet. 2023 Jan;55(1):100-111. doi: 10.1038/s41588-022-01252-3. Epub 2022 Dec 20. Nat Genet. 2023. PMID: 36539616 Free PMC article.
Here we show that TET3, which successively oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other derivatives, prevents aberrant intragenic entry of RNA polymerase II pSer5 into highly expressed genes of airway smooth muscle cells, assuring faithful transcri …
Here we show that TET3, which successively oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other derivatives, prevents aberr …
Priming chromatin for segregation: functional roles of mitotic histone modifications.
Schmitz ML, Higgins JMG, Seibert M. Schmitz ML, et al. Cell Cycle. 2020 Mar;19(6):625-641. doi: 10.1080/15384101.2020.1719585. Epub 2020 Jan 28. Cell Cycle. 2020. PMID: 31992120 Free PMC article. Review.
Through all of these processes, mitotic histone PTMs play a functional role in priming the chromatin for faithful chromosome segregation and preventing genetic instability, one of the characteristic hallmarks of cancer cells....
Through all of these processes, mitotic histone PTMs play a functional role in priming the chromatin for faithful chromosome segregat …
Vitamin D metabolites and the gut microbiome in older men.
Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, Ackermann G, Vanderschueren D, Pauwels S, Knight R, Orwoll ES, Kado DM. Thomas RL, et al. Nat Commun. 2020 Nov 26;11(1):5997. doi: 10.1038/s41467-020-19793-8. Nat Commun. 2020. PMID: 33244003 Free PMC article.
With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA g …
With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 56 …
CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.
Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. Seibert M, et al. J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14. J Cell Biol. 2019. PMID: 30765437 Free PMC article.
Faithful mitotic chromosome segregation is required for the maintenance of genomic stability. ...Injection of phosphorylation-specific H2B S6 antibodies in mitotic cells caused anaphase defects with impaired chromosome segregation and incomplete cytokinesis. As H2B S6ph is …
Faithful mitotic chromosome segregation is required for the maintenance of genomic stability. ...Injection of phosphorylation-specifi …
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.
Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B, Braun S. Murawska M, et al. Cell Rep. 2021 Nov 2;37(5):109944. doi: 10.1016/j.celrep.2021.109944. Cell Rep. 2021. PMID: 34731638 Free PMC article.
Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle. Impeding any of those steps induces heterochromatin defects and improper gene expression. ...
Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful …
Receptive field structures for two celestial compass cues at the input stage of the central complex in the locust brain.
Takahashi N, Zittrell F, Hensgen R, Homberg U. Takahashi N, et al. J Exp Biol. 2022 Feb 15;225(4):jeb243858. doi: 10.1242/jeb.243858. Epub 2022 Feb 23. J Exp Biol. 2022. PMID: 35048987 Free PMC article.
We show that TL neurons have large receptive fields for both types of stimuli. However, faithful integration of polarization angles across the dorsal hemisphere, or matched-filter ability to encode particular sun positions, was found in only two out of 22 recordings. ...
We show that TL neurons have large receptive fields for both types of stimuli. However, faithful integration of polarization angles a …
H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements.
Zink LM, Delbarre E, Eberl HC, Keilhauer EC, Bönisch C, Pünzeler S, Bartkuhn M, Collas P, Mann M, Hake SB. Zink LM, et al. Nucleic Acids Res. 2017 Jun 2;45(10):5691-5706. doi: 10.1093/nar/gkx131. Nucleic Acids Res. 2017. PMID: 28334823 Free PMC article.
Histone chaperones prevent promiscuous histone interactions before chromatin assembly. They guarantee faithful deposition of canonical histones and functionally specialized histone variants into chromatin in a spatial- and temporally-restricted manner. ...
Histone chaperones prevent promiscuous histone interactions before chromatin assembly. They guarantee faithful deposition of canonica …
Unconventional cancer therapy--survey of patients with gynaecological malignancy.
Münstedt K, Kirsch K, Milch W, Sachsse S, Vahrson H. Münstedt K, et al. Arch Gynecol Obstet. 1996;258(2):81-8. doi: 10.1007/BF00626028. Arch Gynecol Obstet. 1996. PMID: 8779615
At the oncological out-patient department of the women's clinic of the Justus-Liebig-University Giessen we conducted a survey of the various unconventional methods used. 38.8% (80/206) of the patients used unconventional therapies, mainly mistletoe extracts (50%), trace mi …
At the oncological out-patient department of the women's clinic of the Justus-Liebig-University Giessen we conducted a survey of the …
Cpf1 protein induced bending of yeast centromere DNA element I.
Niedenthal RK, Sen-Gupta M, Wilmen A, Hegemann JH. Niedenthal RK, et al. Nucleic Acids Res. 1993 Oct 11;21(20):4726-33. doi: 10.1093/nar/21.20.4726. Nucleic Acids Res. 1993. PMID: 8233820 Free PMC article.
The centromere complex is a multicomponent structure essential for faithful chromosome transmission. Here we show that the S. cerevisiae centromere protein Cpf1 bends centromere DNA element I (CDEI) with the bend angle ranging from 66 degrees to 71 degrees. ...
The centromere complex is a multicomponent structure essential for faithful chromosome transmission. Here we show that the S. cerevis …
In vivo analysis of the Saccharomyces cerevisiae centromere CDEIII sequence: requirements for mitotic chromosome segregation.
Jehn B, Niedenthal R, Hegemann JH. Jehn B, et al. Mol Cell Biol. 1991 Oct;11(10):5212-21. doi: 10.1128/mcb.11.10.5212-5221.1991. Mol Cell Biol. 1991. PMID: 1922041 Free PMC article.
In the yeast Saccharomyces cerevisiae, the complete information needed in cis to specify a fully functional mitotic and meiotic centromere is contained within 120 bp arranged in the three conserved centromeric (CEN) DNA elements CDEI, -II, and -III. The 25-bp CDEIII is most impor …
In the yeast Saccharomyces cerevisiae, the complete information needed in cis to specify a fully functional mitotic and meiotic centromere i …
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