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Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A. Wagner J, et al. Among authors: leidel f. Acta Neuropathol. 2013 Jun;125(6):795-813. doi: 10.1007/s00401-013-1114-9. Epub 2013 Apr 19. Acta Neuropathol. 2013. PMID: 23604588 Free PMC article.
Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.
Leidel F, Eiden M, Geissen M, Hirschberger T, Tavan P, Giese A, Kretzschmar HA, Schätzl H, Groschup MH. Leidel F, et al. Biochem Biophys Res Commun. 2014 Feb 28;445(1):23-9. doi: 10.1016/j.bbrc.2014.01.122. Epub 2014 Feb 3. Biochem Biophys Res Commun. 2014. PMID: 24502948