Barriers and Unequal Access to Timely Molecular Testing Results: Addressing the Inequities in Cancer Care Delays across Canada

Curr Oncol. 2024 Mar 6;31(3):1359-1375. doi: 10.3390/curroncol31030103.

Abstract

Genomic medicine is a powerful tool to improve diagnosis and outcomes for cancer patients by facilitating the delivery of the right drug at the right dose at the right time for the right patient. In 2023, a Canadian conference brought together leaders with expertise in different tumor types. The objective was to identify challenges and opportunities for change in terms of equitable and timely access to biomarker testing and reporting at the education, delivery, laboratory, patient, and health-system levels in Canada. Challenges identified included: limited patient and clinician awareness of genomic medicine options with need for formal education strategies; failure by clinicians to discuss genomic medicine with patients; delays in or no access to hereditary testing; lack of timely reporting of results; intra- and inter-provincial disparities in access; lack of funding for patients to access testing and for laboratories to provide testing; lack of standardized testing; and impact of social determinants of health. Canada must standardize its approach to biomarker testing across the country, with a view to addressing current inequities, and prioritize access to advanced molecular testing to ensure systems are in place to quickly bring innovation and evidence-based treatments to Canadian cancer patients, regardless of their place of residence or socioeconomic status.

Keywords: biomarker; biomarker status; biomarker testing; circulating tumor DNA (ctDNA); comprehensive genomic profiling; health systems; liquid biopsy; molecular testing; next generation sequencing; precision medicine.

Publication types

  • Congress

MeSH terms

  • Biomarkers
  • Canada
  • Humans
  • Molecular Diagnostic Techniques
  • Neoplasms* / therapy

Substances

  • Biomarkers