Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Schumacher MA, Hsieh JJ, Liu CY, Appel KL, Waddell A, Almohazey D, Katada K, Bernard JK, Bucar EB, Gadeock S, Maselli KM, Washington MK, Grikscheit TC, Warburton D, Rosen MJ, Frey MR.
Schumacher MA, et al.
Nat Commun. 2021 Feb 5;12(1):836. doi: 10.1038/s41467-021-21113-7.
Nat Commun. 2021.
PMID: 33547321
Free PMC article.
Sprouty2 is downregulated by acute inflammation; this appears to be a protective response, as VillinCre;Sprouty2(F/F) mice are resistant to DSS colitis. In contrast, Sprouty2 is elevated in chronic colitis and in colons of inflammatory bowel disease patients, sugges …
Sprouty2 is downregulated by acute inflammation; this appears to be a protective response, as VillinCre;Sprouty2(F/F) mice are …