Abstract
Malakoplakia is a rare, chronic, granulomatous disease seen in immunocompromised patients, caused by multiple infectious agents, most often bacteria. Microscopically, accumulations of macrophages with granular cytoplasm and intra- or extracellular structures, called Michaelis-Gutmann bodies are characteristic. Main cause of pulmonary malakoplakia is Rhodococcus equi infection. We report two cases of pulmonary malakoplakia, in one case R. equi infection was confirmed. We also present a summary of recent knowledge about the pathogenesis, morphology and clinical course of the disease.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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AIDS-Related Opportunistic Infections / microbiology
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AIDS-Related Opportunistic Infections / pathology*
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Actinomycetales Infections / complications
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Actinomycetales Infections / microbiology
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Actinomycetales Infections / pathology*
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Actinomycetales Infections / therapy
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Adult
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Humans
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Immunocompromised Host
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Lung Diseases / microbiology
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Lung Diseases / pathology*
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Lung Diseases / therapy
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Malacoplakia / etiology
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Malacoplakia / pathology*
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Malacoplakia / therapy
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Male
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Prognosis
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Rhodococcus equi / isolation & purification
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Risk Factors