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Page 1
NSAIDs inhibit tumorigenesis, but how?
Gurpinar E, Grizzle WE, Piazza GA. Gurpinar E, et al. Clin Cancer Res. 2014 Mar 1;20(5):1104-13. doi: 10.1158/1078-0432.CCR-13-1573. Epub 2013 Dec 5. Clin Cancer Res. 2014. PMID: 24311630 Free PMC article. Review.
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Li N, et al. Among authors: gurpinar e. Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26. Mol Cancer Ther. 2013. PMID: 23804703 Free PMC article.
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.
Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, Valiyaveettil J, Chen X, Keeton AB, Piazza GA. Zhu B, et al. Among authors: gurpinar e. Oncotarget. 2017 Aug 27;8(41):69264-69280. doi: 10.18632/oncotarget.20566. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050202 Free PMC article.