The Use of Biosensors to Explore the Potential of Probiotic Strains to Reduce the SOS Response and Mutagenesis in Bacteria

Biosensors (Basel). 2018 Mar 16;8(1):25. doi: 10.3390/bios8010025.

Abstract

A model system based on the Escherichia coli MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated by it. Preliminary attempts to estimate the chemical nature of active components of the fermentates were conducted.

Keywords: E. coli biosensors; antimutagens; probiotic.

MeSH terms

  • Bacillus / metabolism
  • Biosensing Techniques / methods*
  • Ciprofloxacin / toxicity
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Lactobacillus / metabolism
  • Mutagenesis*
  • Mutagens / toxicity
  • Probiotics / metabolism*
  • Rec A Recombinases / genetics
  • SOS Response, Genetics*

Substances

  • Mutagens
  • Ciprofloxacin
  • Rec A Recombinases