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A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor.
Papapetropoulos S, Lee MS, Versavel S, Newbold E, Jinnah HA, Pahwa R, Lyons KE, Elble R, Ondo W, Zesiewicz T, Hedera P, Handforth A, Elder J, Versavel M. Papapetropoulos S, et al. Among authors: newbold e. Mov Disord. 2021 Aug;36(8):1944-1949. doi: 10.1002/mds.28584. Epub 2021 Mar 25. Mov Disord. 2021. PMID: 33764619 Free PMC article. Clinical Trial.
Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.
Delle C, Wang X, Giannetto M, Newbold E, Peng W, Gomolka RS, Ladrón-de-Guevara A, Cankar N, Schiøler Nielsen E, Kjaerby C, Weikop P, Mori Y, Nedergaard M. Delle C, et al. Among authors: newbold e. Fluids Barriers CNS. 2024 Mar 12;21(1):26. doi: 10.1186/s12987-024-00524-w. Fluids Barriers CNS. 2024. PMID: 38475818 Free PMC article.
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of CX-8998, a Selective Modulator of the T-Type Calcium Channel in Inadequately Treated Moderate to Severe Essential Tremor: T-CALM Study Design and Methodology for Efficacy Endpoint and Digital Biomarker Selection.
Papapetropoulos S, Lee MS, Boyer S, Newbold EJ. Papapetropoulos S, et al. Among authors: newbold ej. Front Neurol. 2019 Jun 11;10:597. doi: 10.3389/fneur.2019.00597. eCollection 2019. Front Neurol. 2019. PMID: 31244760 Free PMC article.