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Page 1
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Patnaik A, Axford L, Deng L, Cohick E, Ren X, Loi S, Kecman S, Hollis-Symynkywicz M, Harrison TJ, Papillon JPN, Dales N, Hamann LG, Lee L, Regard JB, Marcinkeviciene J, Marro ML, Patterson AW. Patnaik A, et al. Among authors: cohick e. Bioorg Med Chem. 2020 Jun 15;28(12):115548. doi: 10.1016/j.bmc.2020.115548. Epub 2020 May 12. Bioorg Med Chem. 2020. PMID: 32503688
Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Regard JB, Harrison TJ, Axford J, Axford L, Lee L, Ren X, Deng L, Reynolds A, Mao J, Liu Q, Patnaik A, Cohick E, Hollis-Symynkywicz M, Loi S, Riek S, McKeever U, Dunstan D, Sung M, Ware NF, Brown AP, Hamann LG, Marcinkeviciene J, Patterson AW, Marro ML. Regard JB, et al. Among authors: cohick e. Biochem Pharmacol. 2023 Mar;209:115418. doi: 10.1016/j.bcp.2023.115418. Epub 2023 Jan 21. Biochem Pharmacol. 2023. PMID: 36693437
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.
Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB. Ince TA, et al. Among authors: cohick e. Nat Commun. 2015 Jun 17;6:7419. doi: 10.1038/ncomms8419. Nat Commun. 2015. PMID: 26080861 Free PMC article.
A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity.
D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA. D'Alessio AC, et al. Among authors: cohick e. Stem Cell Reports. 2015 Nov 10;5(5):763-775. doi: 10.1016/j.stemcr.2015.09.016. Stem Cell Reports. 2015. PMID: 26603904 Free PMC article.
Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings.
Schwartz BE, Rajagopal V, Smith C, Cohick E, Whissell G, Gamboa M, Pai R, Sigova A, Grossman I, Bumcrot D, Sasidharan K, Romeo S, Sehgal A, Pingitore P. Schwartz BE, et al. Among authors: cohick e. Cells. 2020 Oct 7;9(10):2247. doi: 10.3390/cells9102247. Cells. 2020. PMID: 33036387 Free PMC article.