Microwave accelerated aza-Claisen rearrangement

Molecules. 2008 Nov 14;13(11):2837-47. doi: 10.3390/molecules131102837.

Abstract

A study of microwave-induced and standard thermal Overman rearrangement of selected allylic trichloroacetimidates 1a-1f, 6-8 to the corresponding acetamides 2a-2f, 9-11 is reported. The microwave-assisted rearrangement of trifluoroacetimidate 13 is also described. Using this methodology, an efficient access to versatile allylic trihaloacetamides building synthons was established.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemical synthesis*
  • Acetamides / chemistry
  • Aza Compounds / chemistry*
  • Imidoesters / chemistry*
  • Isomerism
  • Microwaves*
  • Molecular Structure
  • Temperature

Substances

  • Acetamides
  • Aza Compounds
  • Imidoesters