Abstract
Xymedon (1-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine), a regeneratory and wound-healing drug, exhibited hepatoprotective activity in laboratory animals with experimental toxic hepatitis. Oral drug reduced the severity of toxic involvement of the liver induced by CCl4 and reduced animal mortality. Xymedon promoted recovery of the blood biochemical parameters characterizing the liver status.
MeSH terms
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Alanine Transaminase / metabolism
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Animals
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Animals, Outbred Strains
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Aspartate Aminotransferases / metabolism
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Blood Glucose / metabolism
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Body Weight / drug effects
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Carbon Tetrachloride
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Chemical and Drug Induced Liver Injury / drug therapy*
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Chemical and Drug Induced Liver Injury / metabolism
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Chemical and Drug Induced Liver Injury / pathology
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Liver / drug effects*
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Liver / metabolism
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Liver / pathology
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Mice
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Protective Agents / pharmacology*
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Pyrimidines / pharmacology*
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Rats
Substances
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Blood Glucose
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Protective Agents
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Pyrimidines
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xymedon
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Carbon Tetrachloride
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Aspartate Aminotransferases
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Alanine Transaminase