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tRNA dysregulation and disease.
Orellana EA, Siegal E, Gregory RI. Orellana EA, et al. Nat Rev Genet. 2022 Nov;23(11):651-664. doi: 10.1038/s41576-022-00501-9. Epub 2022 Jun 9. Nat Rev Genet. 2022. PMID: 35681060 Review.
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. Orellana EA, et al. Mol Cell. 2021 Aug 19;81(16):3323-3338.e14. doi: 10.1016/j.molcel.2021.06.031. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352207 Free PMC article.
Structural basis of regulated m7G tRNA modification by METTL1-WDR4.
Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Li J, et al. Among authors: orellana ea. Nature. 2023 Jan;613(7943):391-397. doi: 10.1038/s41586-022-05566-4. Epub 2023 Jan 4. Nature. 2023. PMID: 36599985
No vehicle, no problem.
Orellana EA, Kasinski AL. Orellana EA, et al. Oncotarget. 2017 Oct 27;8(57):96470-96471. doi: 10.18632/oncotarget.22100. eCollection 2017 Nov 14. Oncotarget. 2017. PMID: 29228541 Free PMC article. No abstract available.
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing.
Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. Chen H, et al. Among authors: orellana ea. Cell Res. 2020 Jun;30(6):544-547. doi: 10.1038/s41422-019-0270-4. Epub 2020 Jan 8. Cell Res. 2020. PMID: 31913360 Free PMC article. No abstract available.
12 results