Somatic whole genome dynamics of precancer in Barrett's esophagus reveals features associated with disease progression.
Paulson TG, Galipeau PC, Oman KM, Sanchez CA, Kuhner MK, Smith LP, Hadi K, Shah M, Arora K, Shelton J, Johnson M, Corvelo A, Maley CC, Yao X, Sanghvi R, Venturini E, Emde AK, Hubert B, Imielinski M, Robine N, Reid BJ, Li X.
Paulson TG, et al.
Nat Commun. 2022 Apr 28;13(1):2300. doi: 10.1038/s41467-022-29767-7.
Nat Commun. 2022.
PMID: 35484108
Free PMC article.
Here we use whole genome sequencing to contrast genomic alterations in 427 longitudinal samples from 40 patients with stable Barrett's esophagus compared to 40 Barrett's patients who progressed to esophageal adenocarcinoma (ESAD). We show the same somatic mutational proces …
Here we use whole genome sequencing to contrast genomic alterations in 427 longitudinal samples from 40 patients with stable Barrett's esoph …