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Exploring the role of eRNA in regulating gene expression.
Tan H, Liu T, Zhou T. Tan H, et al. Math Biosci Eng. 2022 Jan;19(2):2095-2119. doi: 10.3934/mbe.2022098. Epub 2021 Dec 28. Math Biosci Eng. 2022. PMID: 35135243 Free article.
Here we introduce a mechanistic model of gene expression to address these issues. This model considers three possible regulation ways of eRNA: Type-I by which eRNA regulates transcriptional activity by facilitating the formation of enhancer-promoter (E-P) loop, Type …
Here we introduce a mechanistic model of gene expression to address these issues. This model considers three possible regulation ways of …
RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms.
Mugunthan S, Wong LL, Winnerdy FR, Summers S, Bin Ismail MH, Foo YH, Jaggi TK, Meldrum OW, Tiew PY, Chotirmall SH, Rice SA, Phan AT, Kjelleberg S, Seviour T. Mugunthan S, et al. Nat Commun. 2023 Nov 27;14(1):7772. doi: 10.1038/s41467-023-43533-3. Nat Commun. 2023. PMID: 38012164 Free PMC article.
However, technical difficulties related to the low stability of RNA make it difficult to understand the precise roles of eRNA in biofilms. Here, we show that eRNA associates with extracellular DNA (eDNA) to form matrix fibres in Pseudomonas aeruginosa biofilms, and …
However, technical difficulties related to the low stability of RNA make it difficult to understand the precise roles of eRNA in biof …
Evoked resonant neural activity in subthalamic local field potentials reflects basal ganglia network dynamics.
Wiest C, He S, Duchet B, Pogosyan A, Benjaber M, Denison T, Hasegawa H, Ashkan K, Baig F, Bertaina I, Morgante F, Pereira EA, Torrecillos F, Tan H. Wiest C, et al. Neurobiol Dis. 2023 Mar;178:106019. doi: 10.1016/j.nbd.2023.106019. Epub 2023 Jan 24. Neurobiol Dis. 2023. PMID: 36706929 Free PMC article.
Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. …
Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. …
Ligand-dependent enhancer activation regulated by topoisomerase-I activity.
Puc J, Kozbial P, Li W, Tan Y, Liu Z, Suter T, Ohgi KA, Zhang J, Aggarwal AK, Rosenfeld MG. Puc J, et al. Cell. 2015 Jan 29;160(3):367-80. doi: 10.1016/j.cell.2014.12.023. Epub 2015 Jan 22. Cell. 2015. PMID: 25619691 Free PMC article.
Furthermore, we show that the DNA nicking activity of TOP1 is a prerequisite for robust eRNA synthesis and enhancer activation and is kinetically accompanied by the recruitment of ATR and the MRN complex, followed by additional components of DNA damage repair machinery to …
Furthermore, we show that the DNA nicking activity of TOP1 is a prerequisite for robust eRNA synthesis and enhancer activation and is …
Subthalamic Nucleus Stimulation-Induced Local Field Potential Changes in Dystonia.
Wiest C, Morgante F, Torrecillos F, Pogosyan A, He S, Baig F, Bertaina I, Hart MG, Edwards MJ, Pereira EA, Tan H. Wiest C, et al. Mov Disord. 2023 Mar;38(3):423-434. doi: 10.1002/mds.29302. Epub 2022 Dec 23. Mov Disord. 2023. PMID: 36562479 Free PMC article.
STN stimulation induced similar spectral changes in dystonia as in Parkinson's disease, such as broadband power suppression, evoked resonant neural activity (ERNA), finely-tuned gamma oscillations, and an increase in aperiodic exponents in STN-LFPs. Both power suppression …
STN stimulation induced similar spectral changes in dystonia as in Parkinson's disease, such as broadband power suppression, evoked resonant …
Finding ARIEL under the sea of T-ALL circuits.
Chiang MY. Chiang MY. Blood. 2019 Jul 18;134(3):219-221. doi: 10.1182/blood.2019001584. Blood. 2019. PMID: 31320362 Free PMC article.
In this issue of Blood, Tan et al report that ARIEL (ARID5B-inducing enhancer-associated long noncoding RNA) is a novel enhancer RNA (eRNA) that amplifies oncogenic transcriptional loops in a subset of T-cell acute lymphoblastic leukemia (T-ALL)....
In this issue of Blood, Tan et al report that ARIEL (ARID5B-inducing enhancer-associated long noncoding RNA) is a novel enhancer RNA …
EMX2OS plays a prognosis-associated enhancer RNA role in gastric cancer.
Liu GX, Tan YZ, He GC, Zhang QL, Liu P. Liu GX, et al. Medicine (Baltimore). 2021 Oct 15;100(41):e27535. doi: 10.1097/MD.0000000000027535. Medicine (Baltimore). 2021. PMID: 34731149 Free PMC article.
The correlation analysis demonstrated the top 10 screened eRNAs and their targeted genes. The results demonstrated that EMX2OS was ranked as the top eRNA according to the results of the Kaplan-Meier analysis. The correlation analysis demonstrated that eRNA EMX2OS is …
The correlation analysis demonstrated the top 10 screened eRNAs and their targeted genes. The results demonstrated that EMX2OS was ranked as …
An enhancer RNA-based risk model for prediction of bladder cancer prognosis.
Xu Z, Xu C, Wang Q, Ma S, Li Y, Liu S, Peng S, Tan J, Zhao X, Han D, Zhang K, Yang L. Xu Z, et al. Front Med (Lausanne). 2022 Sep 14;9:979542. doi: 10.3389/fmed.2022.979542. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36186809 Free PMC article.
However, commonly used predictive tools cannot meet clinical needs because of their insufficient accuracy. METHODS: We have developed an enhancer RNA (eRNA)-based signature to improve the prediction for bladder cancer prognosis. ...Then, we constructed a risk model for pro …
However, commonly used predictive tools cannot meet clinical needs because of their insufficient accuracy. METHODS: We have developed an enh …
Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program.
Tan Y, Jin C, Ma W, Hu Y, Tanasa B, Oh S, Gamliel A, Ma Q, Yao L, Zhang J, Ohgi K, Liu W, Aggarwal AK, Rosenfeld MG. Tan Y, et al. Mol Cell. 2018 Aug 16;71(4):526-539.e8. doi: 10.1016/j.molcel.2018.07.039. Mol Cell. 2018. PMID: 30118678 Free PMC article.
Rather, KDM2A tethers the E3 ubiquitin-protein ligase NEDD4 to ubiquitylate/dismiss Pol II to abrogate eRNA transcription, with consequent target gene downregulation. Thus, our data reveal that Pol II ubiquitylation/dismissal may serve as a potentially broad strategy utili …
Rather, KDM2A tethers the E3 ubiquitin-protein ligase NEDD4 to ubiquitylate/dismiss Pol II to abrogate eRNA transcription, with conse …
Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.
Wiest C, Tinkhauser G, Pogosyan A, Bange M, Muthuraman M, Groppa S, Baig F, Mostofi A, Pereira EA, Tan H, Brown P, Torrecillos F. Wiest C, et al. Neurobiol Dis. 2020 Sep;143:105019. doi: 10.1016/j.nbd.2020.105019. Epub 2020 Jul 16. Neurobiol Dis. 2020. PMID: 32681881 Free PMC article.
During long stimulation blocks, the frequency and amplitude of the ERNA decreased before reaching a steady state after ~70 s. Maximal ERNA amplitudes diminished over repeated stimulation blocks. Upon DBS cessation, the ERNA was revealed as an under-damped osc …
During long stimulation blocks, the frequency and amplitude of the ERNA decreased before reaching a steady state after ~70 s. Maximal …
11 results