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Showing results for erad er
Search for Eray Er instead (1 results)
Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.
Hwang J, Qi L. Hwang J, et al. Trends Biochem Sci. 2018 Aug;43(8):593-605. doi: 10.1016/j.tibs.2018.06.005. Epub 2018 Jun 29. Trends Biochem Sci. 2018. PMID: 30056836 Free PMC article. Review.
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for the clearance of misfolded proteins in the ER for cytosolic proteasomal degrad …
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control m …
N-glycan processing selects ERAD-resistant misfolded proteins for ER-to-lysosome-associated degradation.
Fregno I, Fasana E, Soldà T, Galli C, Molinari M. Fregno I, et al. EMBO J. 2021 Aug 2;40(15):e107240. doi: 10.15252/embj.2020107240. Epub 2021 Jun 21. EMBO J. 2021. PMID: 34152647 Free PMC article.
Strikingly, the major biosynthetic compartment in eukaryotic cells, the endoplasmic reticulum (ER), lacks degradative machineries. Misfolded proteins in the ER are translocated to the cytosol for proteasomal degradation via ER-associated degradation (ERAD …
Strikingly, the major biosynthetic compartment in eukaryotic cells, the endoplasmic reticulum (ER), lacks degradative machineries. Mi …
Endoplasmic Reticulum-Associated Protein Degradation.
Krshnan L, van de Weijer ML, Carvalho P. Krshnan L, et al. Cold Spring Harb Perspect Biol. 2022 Dec 1;14(12):a041247. doi: 10.1101/cshperspect.a041247. Cold Spring Harb Perspect Biol. 2022. PMID: 35940909 Review.
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated degradation (ERAD). ...ERAD also targets a restricted set of folded proteins to influen …
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in th …
Lipids and their (un)known effects on ER-associated protein degradation (ERAD).
Goder V, Alanis-Dominguez E, Bustamante-Sequeiros M. Goder V, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan;1865(1):158488. doi: 10.1016/j.bbalip.2019.06.014. Epub 2019 Jun 24. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31233887 Review.
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a conserved cellular process that apart from protein quality control and maintenance of ER membrane identity has pivotal functions in regulating the lipid composition of the ER membran …
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a conserved cellular process that apart from protein quali …
Rate of ER-associated degradation (ERAD) of misfolded proteins in Saccharomyces cerevisiae.
Hosomi A. Hosomi A. 2021 Oct 1 [updated 2022 Mar 18]. In: Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021–. 2021 Oct 1 [updated 2022 Mar 18]. In: Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021–. PMID: 37590572 Free Books & Documents. Review. No abstract available.
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD.
Molinari M. Molinari M. Dev Cell. 2021 Apr 5;56(7):949-966. doi: 10.1016/j.devcel.2021.03.005. Epub 2021 Mar 24. Dev Cell. 2021. PMID: 33765438 Free article. Review.
ER-phagy receptors are activated by a variety of pleiotropic and ER-centric stimuli. ...They cooperate with unfolded protein responses (UPRs) and with ER-associated degradation (ERAD) in determining ER size, function, and homeostasis....
ER-phagy receptors are activated by a variety of pleiotropic and ER-centric stimuli. ...They cooperate with unfolded protein r …
Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways.
Fregno I, Molinari M. Fregno I, et al. Crit Rev Biochem Mol Biol. 2019 Apr;54(2):153-163. doi: 10.1080/10409238.2019.1610351. Epub 2019 May 14. Crit Rev Biochem Mol Biol. 2019. PMID: 31084437 Review.
The ER does not contain degradative devices and the majority of misfolded proteins generated in this biosynthetic compartment are dislocated across the membrane for degradation by cytosolic 26S proteasomes by mechanisms and pathways collectively defined as ER-associ …
The ER does not contain degradative devices and the majority of misfolded proteins generated in this biosynthetic compartment are dis …
ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER.
Bernasconi R, Molinari M. Bernasconi R, et al. Curr Opin Cell Biol. 2011 Apr;23(2):176-83. doi: 10.1016/j.ceb.2010.10.002. Curr Opin Cell Biol. 2011. PMID: 21075612 Free PMC article. Review.
At steady state, this is prevented by ERAD tuning, that is, the removal of select ERAD regulators from the ER and their degradation by proteasomes and by endo-lysosomal proteases. In Coronaviruses infected cells, the formation of LC3-I coated vesicles contain …
At steady state, this is prevented by ERAD tuning, that is, the removal of select ERAD regulators from the ER and their …
Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?
Morito D, Nagata K. Morito D, et al. Mol Cell. 2015 Aug 6;59(3):335-44. doi: 10.1016/j.molcel.2015.06.010. Mol Cell. 2015. PMID: 26253026 Free article. Review.
ER-associated degradation (ERAD) is a protein clearance mechanism by which misfolded, misassembled, or metabolically regulated proteins are specifically dislocated from the ER into the cytosol and degraded by the ubiquitin proteasome system. ERAD very …
ER-associated degradation (ERAD) is a protein clearance mechanism by which misfolded, misassembled, or metabolically regulated …
Mechanisms of substrate processing during ER-associated protein degradation.
Christianson JC, Jarosch E, Sommer T. Christianson JC, et al. Nat Rev Mol Cell Biol. 2023 Nov;24(11):777-796. doi: 10.1038/s41580-023-00633-8. Epub 2023 Aug 1. Nat Rev Mol Cell Biol. 2023. PMID: 37528230 Review.
ER-associated protein degradation (ERAD) collectively describes this specialized arm of protein quality control via the ubiquitin-proteasome system. ...Not surprisingly, ER-membrane-embedded ubiquitin ligases (ER-E3s) act as central hubs for each of th …
ER-associated protein degradation (ERAD) collectively describes this specialized arm of protein quality control via the ubiqui …
1,628 results