Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review

Emmy Marjorie Carvalho de Araújo; Marcos Adriano Garcia Campos; Andressa Monteiro Sodré; Maria Izabel de Holanda; Rodrigo Hagemann; Antonio Augusto Lima Teixeira Júnior; Natalino Salgado Filho; Precil Diego Miranda de Menezes Neves; Gyl Eanes Barros Silva

doi:10.3390/vaccines12010062

Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review

Vaccines (Basel). 2024 Jan 8;12(1):62. doi: 10.3390/vaccines12010062.

Authors

Emmy Marjorie Carvalho de Araújo¹, Marcos Adriano Garcia Campos², Andressa Monteiro Sodré¹, Maria Izabel de Holanda³, Rodrigo Hagemann⁴, Antonio Augusto Lima Teixeira Júnior⁵, Natalino Salgado Filho¹, Precil Diego Miranda de Menezes Neves⁶, Gyl Eanes Barros Silva^{1

7}

Affiliations

¹ Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil.
² Clinical Hospital of Botucatu Medical School, São Paulo State University, Professor Mário Rubens Guimarães Montenegro Avenue, Botucatu 18618-687, Brazil.
³ Bonsucesso Federal Hospital, Londres Avenue, Rio de Janeiro 21041-020, Brazil.
⁴ Clinical Hospital Complex, Federal University of Paraná, General Carneiro Street, Curitiba 80060-900, Brazil.
⁵ Departament of Genetics, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto 14040-900, Brazil.
⁶ Clinical Hospital, University of São Paulo, Dr. Ovídio Pires de Campos Street, São Paulo 05403-010, Brazil.
⁷ Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto 14040-900, Brazil.

Abstract

Large-scale COVID-19 vaccination has been one of the most effective strategies to control the spread of the SARS-CoV-2 virus. However, several cases of glomerular injury related to the COVID-19 vaccine have been described in the literature. We report two cases of a tip lesion variant of focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, the tip lesion variant of FSGS is currently the most frequent variant associated with vaccination against COVID-19. Prognosis is favorable and without significant alterations in the tubulointerstitial or vascular compartments. Adverse effects of vaccines need to be recognized early and will help us to understand the immune and pathological mechanisms of kidney damage.

Keywords: COVID-19; SARS-CoV-2; focal segmental glomerulosclerosis; kidney biopsy; vaccine.

Publication types

Case Reports

Grants and funding

This research received no external funding.