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Year Number of Results
2013 1
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2022 2
2023 3
2024 2

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Page 1
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
Lindberg MF, Deau E, Miege F, Greverie M, Roche D, George N, George P, Merlet L, Gavard J, Brugman SJT, Aret E, Tinnemans P, de Gelder R, Sadownik J, Verhofstad E, Sleegers D, Santangelo S, Dairou J, Fernandez-Blanco Á, Dierssen M, Krämer A, Knapp S, Meijer L. Lindberg MF, et al. Among authors: deau e. J Med Chem. 2023 Dec 14;66(23):15648-15670. doi: 10.1021/acs.jmedchem.3c01888. Epub 2023 Dec 5. J Med Chem. 2023. PMID: 38051674
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
Lana-Elola E, Aoidi R, Llorian M, Gibbins D, Buechsenschuetz C, Bussi C, Flynn H, Gilmore T, Watson-Scales S, Haugsten Hansen M, Hayward D, Song OR, Brault V, Herault Y, Deau E, Meijer L, Snijders AP, Gutierrez MG, Fisher EMC, Tybulewicz VLJ. Lana-Elola E, et al. Among authors: deau e. Sci Transl Med. 2024 Jan 24;16(731):eadd6883. doi: 10.1126/scitranslmed.add6883. Epub 2024 Jan 24. Sci Transl Med. 2024. PMID: 38266108 Free PMC article.
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, Sévère E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, Burgy G, Guiheneuf S, Herault Y, Kendall DA, Carreaux F, Bazureau JP, Meijer L. Tahtouh T, et al. Among authors: deau e. J Med Chem. 2022 Jan 27;65(2):1396-1417. doi: 10.1021/acs.jmedchem.1c01141. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928152
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S. El Khamlichi C, et al. Among authors: deau e. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2118847119. doi: 10.1073/pnas.2118847119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594393 Free PMC article.
Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Carey-Smith SL, Simad MH, Panchal K, Aya-Bonilla C, Smolders H, Lin S, Armitage JD, Nguyen VT, Bentley K, Ford J, Singh S, Oommen J, Laurent AP, Mercher T, Crispino JD, Montgomery AP, Kassiou M, Besson T, Deau E, Meijer L, Cheung LC, Kotecha RS, Malinge S. Carey-Smith SL, et al. Among authors: deau e. Haematologica. 2024 Feb 29. doi: 10.3324/haematol.2023.284271. Online ahead of print. Haematologica. 2024. PMID: 38426275 Free article.
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