Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Jeffrey Corsaut; Elmer Soto; Heather Biernaski; Michael S Kovacs; Keith St Lawrence; Justin W Hicks

doi:10.3390/diagnostics14090902

Frugal and Translatable [¹⁵O]O₂ Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Diagnostics (Basel). 2024 Apr 25;14(9):902. doi: 10.3390/diagnostics14090902.

Authors

Jeffrey Corsaut^{1

2}, Elmer Soto^{1

2}, Heather Biernaski^{1

2}, Michael S Kovacs^{1

2

3

4}, Keith St Lawrence^{1

2

4}, Justin W Hicks^{1

2

4}

Affiliations

¹ Lawson Health Research Institute, London, ON N6A 5W9, Canada.
² Saint Joseph's Health Canada London, London, ON N6A 4V2, Canada.
³ Department of Medical Imaging, Western University, London, ON N6A 3K7, Canada.
⁴ Department of Medical Biophysics, Western University, London, ON N6A 3K7, Canada.

Abstract

Oxygen-15 (β+, t_1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [¹⁵O]O₂ over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.

Keywords: GMP; cerebral metabolic rate of oxygen; hybrid PET/MR; oxygen-15; positron emission tomography; radiation safety.

Grants and funding

469003/CAPMC/ CIHR/Canada