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Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.
Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B. Replogle JM, et al. Among authors: meer ej. Nat Biotechnol. 2020 Aug;38(8):954-961. doi: 10.1038/s41587-020-0470-y. Epub 2020 Mar 30. Nat Biotechnol. 2020. PMID: 32231336 Free PMC article.
The macula densa prorenin receptor is essential in renin release and blood pressure control.
Riquier-Brison ADM, Sipos A, Prókai Á, Vargas SL, Toma L, Meer EJ, Villanueva KG, Chen JCM, Gyarmati G, Yih C, Tang E, Nadim B, Pendekanti S, Garrelds IM, Nguyen G, Danser AHJ, Peti-Peterdi J. Riquier-Brison ADM, et al. Among authors: meer ej. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F521-F534. doi: 10.1152/ajprenal.00029.2018. Epub 2018 Apr 18. Am J Physiol Renal Physiol. 2018. PMID: 29667908 Free PMC article.
The collecting duct is the major source of prorenin in diabetes.
Kang JJ, Toma I, Sipos A, Meer EJ, Vargas SL, Peti-Peterdi J. Kang JJ, et al. Among authors: meer ej. Hypertension. 2008 Jun;51(6):1597-604. doi: 10.1161/HYPERTENSIONAHA.107.107268. Epub 2008 Apr 14. Hypertension. 2008. PMID: 18413493 Free PMC article.