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Page 1
Design, synthesis and biological activity of novel molecules designed to target PARP and DNA.
Bioorg Med Chem Lett. 2017 Feb 1;27(3):688-694. doi: 10.1016/j.bmcl.2016.09.054. Epub 2016 Sep 22.
Bioorg Med Chem Lett. 2017.
PMID: 28003142
Design and Synthesis of a Trifunctional Molecular System "Programmed" to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells.
Schmitt J, Huang S, Goodfellow E, Williams C, Jean-Claude BJ.
Schmitt J, et al. Among authors: goodfellow e.
J Med Chem. 2020 Jun 11;63(11):5752-5762. doi: 10.1021/acs.jmedchem.9b02008. Epub 2020 Jun 2.
J Med Chem. 2020.
PMID: 32484346
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Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules.
Schmitt J, Goodfellow E, Huang S, Williams C, Gomes INF, Rosa MN, Reis RM, Yang R, Titi HM, Jean-Claude BJ.
Schmitt J, et al. Among authors: goodfellow e.
Eur J Med Chem. 2020 Apr 15;192:112185. doi: 10.1016/j.ejmech.2020.112185. Epub 2020 Feb 26.
Eur J Med Chem. 2020.
PMID: 32145644
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A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Senhaji Mouhri Z, Goodfellow E, Jean-Claude B.
Senhaji Mouhri Z, et al. Among authors: goodfellow e.
BMC Cancer. 2017 Aug 11;17(1):540. doi: 10.1186/s12885-017-3504-1.
BMC Cancer. 2017.
PMID: 28800752
Free PMC article.
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15N-, 13C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene.
Senhaji Mouhri Z, Goodfellow E, Kelley SP, Stein RS, Rogers RD, J Jean-Claude B.
Senhaji Mouhri Z, et al. Among authors: goodfellow e.
Molecules. 2017 Jul 19;22(7):1183. doi: 10.3390/molecules22071183.
Molecules. 2017.
PMID: 28753938
Free PMC article.
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