Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells

Cell Biol Int. 2014 Jul;38(7):799-802. doi: 10.1002/cbin.10262. Epub 2014 Mar 28.

Abstract

Mitochondrial permeabilisation after NO donor application did not activate caspase-9. We have studied the X-linked apoptosis inhibitor (XIAP) and Aven protein content in NO-treated Jurkat cells. The level of both proteins increased in NO-treated cells. Thus the increase in XIAP and Aven content could be the cause of the lack of caspase-9 activity after mitochondrial permeabilisation in NO-treated Jurkat cells.

Keywords: Aven; XIAP; apoptosis; caspase; mitochondria; nitric oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Apoptosis / drug effects
  • Apoptosis Regulatory Proteins / metabolism*
  • Caspase 9 / metabolism
  • Humans
  • Jurkat Cells
  • Membrane Potential, Mitochondrial / drug effects
  • Membrane Proteins / metabolism*
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Nitric Oxide Donors / pharmacology*
  • Permeability / drug effects
  • Triazenes / pharmacology*
  • X-Linked Inhibitor of Apoptosis Protein / metabolism*

Substances

  • 1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene
  • AVEN protein, human
  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • Membrane Proteins
  • Nitric Oxide Donors
  • Triazenes
  • X-Linked Inhibitor of Apoptosis Protein
  • Caspase 9