α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

Ekaterina A Verochkina; Nadezhda Victorovna Vchislo; Igor B Rozentsveig

doi:10.3390/molecules26144297

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

Molecules. 2021 Jul 15;26(14):4297. doi: 10.3390/molecules26144297.

Authors

Ekaterina A Verochkina¹, Nadezhda Victorovna Vchislo¹, Igor B Rozentsveig¹

Affiliation

¹ A. E. Favorsky Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia.

Abstract

α-Functionalized α,β-unsaturated aldehydes is an important class of compounds, which are widely used in fine organic synthesis, biology, medicine and pharmacology, chemical industry, and agriculture. Some of the 2-substituted 2-alkenals are found to be the key metabolites in plant and animal cells. Therefore, the development of efficient methods for their synthesis attracts the attention of organic chemists. This review focusses on the recent advances in the synthesis of 2-functionally substituted 2-alkenals. The approaches to the preparation of α-alkyl α,β-unsaturated aldehydes are not included in this review.

Keywords: 2-functionally substituted 2-alkenals; aldol reactions; building blocks; organocatalysis; precursors; synthesis; α-functionally substituted α,β-unsaturated aldehydes.

Publication types

Review