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Page 1
The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.
Vaca HR, Celentano AM, Toscanini MA, Heimburg T, Ghazy E, Zeyen P, Hauser AT, Oliveira G, Elissondo MC, Jung M, Sippl W, Camicia F, Rosenzvit MC. Vaca HR, et al. Among authors: ghazy e. PLoS Negl Trop Dis. 2021 Mar 3;15(3):e0009226. doi: 10.1371/journal.pntd.0009226. eCollection 2021 Mar. PLoS Negl Trop Dis. 2021. PMID: 33657105 Free PMC article.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, Ridinger J, Robaa D, Schmidtkunz K, Erdmann F, Schmidt M, Romier C, Jung M, Oehme I, Sippl W. Darwish S, et al. Among authors: ghazy e. Int J Mol Sci. 2022 Jul 7;23(14):7535. doi: 10.3390/ijms23147535. Int J Mol Sci. 2022. PMID: 35886887 Free PMC article.
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Ghazy E, Heimburg T, Lancelot J, Zeyen P, Schmidtkunz K, Truhn A, Darwish S, Simoben CV, Shaik TB, Erdmann F, Schmidt M, Robaa D, Romier C, Jung M, Pierce R, Sippl W. Ghazy E, et al. Eur J Med Chem. 2021 Dec 5;225:113745. doi: 10.1016/j.ejmech.2021.113745. Epub 2021 Aug 8. Eur J Med Chem. 2021. PMID: 34392190
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
Heimburg T, Kolbinger FR, Zeyen P, Ghazy E, Herp D, Schmidtkunz K, Melesina J, Shaik TB, Erdmann F, Schmidt M, Romier C, Robaa D, Witt O, Oehme I, Jung M, Sippl W. Heimburg T, et al. Among authors: ghazy e. J Med Chem. 2017 Dec 28;60(24):10188-10204. doi: 10.1021/acs.jmedchem.7b01447. Epub 2017 Dec 15. J Med Chem. 2017. PMID: 29190092
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis.
Ângelo de Souza L, Silva E Bastos M, de Melo Agripino J, Souza Onofre T, Apaza Calla LF, Heimburg T, Ghazy E, Bayer T, Ferraz da Silva VH, Dutra Ribeiro P, Licursi de Oliveira L, Costa Bressan G, de Almeida Lamêgo MR, Silva-Júnior A, de Souza Vasconcellos R, Suarez-Fontes AM, Almeida-Silva J, Vannier-Santos MA, Pierce R, Sippl W, Lopes Rangel Fietto J. Ângelo de Souza L, et al. Among authors: ghazy e. Biochem Pharmacol. 2020 Oct;180:114191. doi: 10.1016/j.bcp.2020.114191. Epub 2020 Aug 7. Biochem Pharmacol. 2020. PMID: 32777278
11 results