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Page 1
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
Szabó KE, Kyriakis E, Psarra AG, Karra AG, Sipos Á, Docsa T, Stravodimos GA, Katsidou E, Skamnaki VT, Liggri PGV, Zographos SE, Mándi A, Király SB, Kurtán T, Leonidas DD, Somsák L. Szabó KE, et al. Among authors: kyriakis e. J Med Chem. 2019 Jul 11;62(13):6116-6136. doi: 10.1021/acs.jmedchem.9b00356. Epub 2019 Jun 28. J Med Chem. 2019. PMID: 31251604
Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Kyriakis E, Solovou TGA, Kun S, Czifrák K, Szőcs B, Juhász L, Bokor É, Stravodimos GA, Kantsadi AL, Chatzileontiadou DSM, Skamnaki VT, Somsák L, Leonidas DD. Kyriakis E, et al. Bioorg Chem. 2018 Apr;77:485-493. doi: 10.1016/j.bioorg.2018.02.008. Epub 2018 Feb 12. Bioorg Chem. 2018. PMID: 29454281
Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.
Leonidas DD, Zographos SE, Tsitsanou KE, Skamnaki VT, Stravodimos G, Kyriakis E. Leonidas DD, et al. Among authors: kyriakis e. Acta Crystallogr F Struct Biol Commun. 2021 Sep 1;77(Pt 9):303-311. doi: 10.1107/S2053230X21008542. Epub 2021 Aug 26. Acta Crystallogr F Struct Biol Commun. 2021. PMID: 34473107 Free PMC article.
Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase.
Stravodimos GA, Kantsadi AL, Apostolou A, Kyriakis E, Kafaski-Kanelli VN, Solovou T, Gatzona P, Liggri PGV, Theofanous S, Gorgogietas VA, Kissa A, Psachoula C, Lemonakis A, Chatzileontiadou DSM, Psarra AG, Skamnaki VT, Haroutounian SA, Leonidas DD. Stravodimos GA, et al. Among authors: kyriakis e. Curr Drug Discov Technol. 2018;15(1):41-53. doi: 10.2174/1570163814666170619091736. Curr Drug Discov Technol. 2018. PMID: 28625148
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.
Chetter BA, Kyriakis E, Barr D, Karra AG, Katsidou E, Koulas SM, Skamnaki VT, Snape TJ, Psarra AG, Leonidas DD, Hayes JM. Chetter BA, et al. Among authors: kyriakis e. Bioorg Chem. 2020 Sep;102:104003. doi: 10.1016/j.bioorg.2020.104003. Epub 2020 Jun 10. Bioorg Chem. 2020. PMID: 32771768
High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors.
Fischer T, Koulas SM, Tsagkarakou AS, Kyriakis E, Stravodimos GA, Skamnaki VT, Liggri PGV, Zographos SE, Riedl R, Leonidas DD. Fischer T, et al. Among authors: kyriakis e. Molecules. 2019 Apr 3;24(7):1322. doi: 10.3390/molecules24071322. Molecules. 2019. PMID: 30987252 Free PMC article.
15 results