The aim of this article is to verify the influence of tuberculosis on mass tourism architecture. To achieve this, the paper analyses the typological evolution of the hotel since the middle of the nineteenth century, when the first sanatoria appeared in the alpine resorts. A study that creates links between the progress in architecture and the medical therapy advances. The goal is to highlight the hybridisation process between both architectural typologies. Although this overlapping is developed until the Second World War, the influence of its mixture is still present in contemporary mass tourism architecture.