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Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.
Stem Cell Res. 2011 May;6(3):195-205. doi: 10.1016/j.scr.2011.01.002. Epub 2011 Jan 19.
Stem Cell Res. 2011.
PMID: 21353660
Free PMC article.
Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.
Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S.
Ruthel G, et al. Among authors: torres melendez e.
Toxins (Basel). 2011 Mar;3(3):207-17. doi: 10.3390/toxins3030207. Epub 2011 Mar 15.
Toxins (Basel). 2011.
PMID: 22069707
Free PMC article.
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Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies.
Nuss JE, Ruthel G, Tressler LE, Wanner LM, Torres-Melendez E, Hale ML, Bavari S.
Nuss JE, et al. Among authors: torres melendez e.
J Biomol Screen. 2010 Jan;15(1):42-51. doi: 10.1177/1087057109354779. Epub 2009 Dec 4.
J Biomol Screen. 2010.
PMID: 19965805
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Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.
Stahl AM, Ruthel G, Torres-Melendez E, Kenny TA, Panchal RG, Bavari S.
Stahl AM, et al. Among authors: torres melendez e.
J Biomol Screen. 2007 Apr;12(3):370-7. doi: 10.1177/1087057106299163. Epub 2007 Mar 1.
J Biomol Screen. 2007.
PMID: 17332092
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