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2005 2
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Showing results for ecm atlas
Your search for Ecem Altaş retrieved no results
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. Yang AC, et al. Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14. Nature. 2022. PMID: 35165441 Free PMC article.
We discover two subtypes of human pericytes, marked by solute transport and extracellular matrix (ECM) organization; and define perivascular versus meningeal fibroblast specialization. In Alzheimer's disease, we observe selective vulnerability of ECM-maintaining per …
We discover two subtypes of human pericytes, marked by solute transport and extracellular matrix (ECM) organization; and define periv …
Single-cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity.
Wang Z, Chai C, Wang R, Feng Y, Huang L, Zhang Y, Xiao X, Yang S, Zhang Y, Zhang X. Wang Z, et al. Clin Transl Med. 2021 Dec;11(12):e650. doi: 10.1002/ctm2.650. Clin Transl Med. 2021. PMID: 34965030 Free PMC article.
Advanced single-cell RNA sequencing (scRNA-seq) is a robust tool used to analyse for dissecting cellular heterogeneity. However, the comprehensive single-cell atlas for human MSCs has not been achieved. METHODS: This study used massive parallel multiplexing scRNA-seq to co …
Advanced single-cell RNA sequencing (scRNA-seq) is a robust tool used to analyse for dissecting cellular heterogeneity. However, the compreh …
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.
Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner C, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C, Kobold S. Gottschlich A, et al. Nat Biotechnol. 2023 Nov;41(11):1618-1632. doi: 10.1038/s41587-023-01684-0. Epub 2023 Mar 13. Nat Biotechnol. 2023. PMID: 36914885 Free PMC article.
Chimeric antigen receptor T cells (CAR-T cells) have emerged as a powerful treatment option for individuals with B cell malignancies but have yet to achieve success in treating acute myeloid leukemia (AML) due to a lack of safe targets. Here we leveraged an atlas of public …
Chimeric antigen receptor T cells (CAR-T cells) have emerged as a powerful treatment option for individuals with B cell malignancies but hav …
The extracellular matrix: Tools and insights for the "omics" era.
Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO. Naba A, et al. Matrix Biol. 2016 Jan;49:10-24. doi: 10.1016/j.matbio.2015.06.003. Epub 2015 Jul 8. Matrix Biol. 2016. PMID: 26163349 Free PMC article. Review.
In this review, we describe new bioinformatic tools and experimental strategies for ECM research, and illustrate how these tools and approaches can be exploited to provide novel insights in our understanding of ECM biology. We also introduce a web platform "the matr …
In this review, we describe new bioinformatic tools and experimental strategies for ECM research, and illustrate how these tools and …
A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy.
Che LH, Liu JW, Huo JP, Luo R, Xu RM, He C, Li YQ, Zhou AJ, Huang P, Chen YY, Ni W, Zhou YX, Liu YY, Li HY, Zhou R, Mo H, Li JM. Che LH, et al. Cell Discov. 2021 Sep 7;7(1):80. doi: 10.1038/s41421-021-00312-y. Cell Discov. 2021. PMID: 34489408 Free PMC article.
By contrast, in tumors treated with PC, we found activation of B cells, lower diversity of TAMs with immature and less activated phenotype, lower abundance of both dysfunctional T cells and ECM-remodeling cancer-associated fibroblasts, and an accumulation of myofibroblasts …
By contrast, in tumors treated with PC, we found activation of B cells, lower diversity of TAMs with immature and less activated phenotype, …
Integrins as attractive targets for cancer therapeutics.
Li M, Wang Y, Li M, Wu X, Setrerrahmane S, Xu H. Li M, et al. Acta Pharm Sin B. 2021 Sep;11(9):2726-2737. doi: 10.1016/j.apsb.2021.01.004. Epub 2021 Apr 10. Acta Pharm Sin B. 2021. PMID: 34589393 Free PMC article. Review.
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis.
Dou S, Wang Q, Zhang B, Wei C, Wang H, Liu T, Duan H, Jiang H, Liu M, Qi X, Zhou Q, Xie L, Shi W, Gao H. Dou S, et al. Cell Discov. 2022 Jul 12;8(1):66. doi: 10.1038/s41421-022-00397-z. Cell Discov. 2022. PMID: 35821117 Free PMC article.
We confirmed the central role of corneal stromal cells in this disease, where dysregulation of collagen and extracellular matrix (ECM) occurred. Differential gene expression and histological analyses revealed two potential novel markers for keratoconus stromal cells, namel …
We confirmed the central role of corneal stromal cells in this disease, where dysregulation of collagen and extracellular matrix (ECM …
Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer.
Guo Q, Zhao L, Yan N, Li Y, Guo C, Dang S, Shen X, Han J, Luo Y. Guo Q, et al. Front Immunol. 2023 Mar 13;14:1148056. doi: 10.3389/fimmu.2023.1148056. eCollection 2023. Front Immunol. 2023. PMID: 36993958 Free PMC article.
Gene function enrichment analyses revealed that genes that were co-expressed with TPM4 were enriched within the extracellular matrix (ECM)-related pathways. Wound-healing and (Matrigel) transwell assays revealed that TPM4 promotes cell migration and invasion. ...TPM4 may f …
Gene function enrichment analyses revealed that genes that were co-expressed with TPM4 were enriched within the extracellular matrix (ECM …
Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse.
Li Y, Zhang QY, Sun BF, Ma Y, Zhang Y, Wang M, Ma C, Shi H, Sun Z, Chen J, Yang YG, Zhu L. Li Y, et al. Nat Commun. 2021 Jan 4;12(1):87. doi: 10.1038/s41467-020-20358-y. Nat Commun. 2021. PMID: 33397933 Free PMC article.
Despite recent advances in AVP diagnosis and treatment, a cell atlas of the vaginal wall in AVP has not been constructed. Here, we employ single-cell RNA-seq to construct a transcriptomic atlas of 81,026 individual cells in the vaginal wall from AVP and control samp …
Despite recent advances in AVP diagnosis and treatment, a cell atlas of the vaginal wall in AVP has not been constructed. Here, we em …
The cycling and aging mouse female reproductive tract at single-cell resolution.
Winkler I, Tolkachov A, Lammers F, Lacour P, Daugelaite K, Schneider N, Koch ML, Panten J, Grünschläger F, Poth T, Ávila BM, Schneider A, Haas S, Odom DT, Gonçalves Â. Winkler I, et al. Cell. 2024 Feb 15;187(4):981-998.e25. doi: 10.1016/j.cell.2024.01.021. Epub 2024 Feb 6. Cell. 2024. PMID: 38325365 Free article.
These analyses reveal that fibroblasts play central-and highly organ-specific-roles in FRT remodeling by orchestrating extracellular matrix (ECM) reorganization and inflammation. Our results suggest a model wherein recurrent FRT remodeling over reproductive lifespan drives …
These analyses reveal that fibroblasts play central-and highly organ-specific-roles in FRT remodeling by orchestrating extracellular matrix …
371 results