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Showing results for ber genes
Your search for Eber Lenes retrieved no results
Biomarker-Guided Development of DNA Repair Inhibitors.
Cleary JM, Aguirre AJ, Shapiro GI, D'Andrea AD. Cleary JM, et al. Mol Cell. 2020 Jun 18;78(6):1070-1085. doi: 10.1016/j.molcel.2020.04.035. Epub 2020 May 26. Mol Cell. 2020. PMID: 32459988 Free PMC article. Review.
For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, BRCA2, or other genes in the Fanconi anemia/BRCA pathway, and these tumors have been shown to be particularly sensitive to inhibitors of the …
For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, BRCA2, …
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E. Krwawicz J, et al. Acta Biochim Pol. 2007;54(3):413-34. Epub 2007 Sep 24. Acta Biochim Pol. 2007. PMID: 17893748 Review.
Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escheri …
Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides i …
Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy.
Ashraf S, Deshpande N, Vasanth S, Melangath G, Wong RJ, Zhao Y, Price MO, Price FW Jr, Jurkunas UV. Ashraf S, et al. Exp Eye Res. 2023 Jun;231:109499. doi: 10.1016/j.exer.2023.109499. Epub 2023 May 9. Exp Eye Res. 2023. PMID: 37169279 Free PMC article.
FECD specimens exhibited downregulation of 9 genes and upregulation of 8 genes belonging to the four major DNA repair pathways, namely, base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), and double strand break (DSB) repair, …
FECD specimens exhibited downregulation of 9 genes and upregulation of 8 genes belonging to the four major DNA repair pathways …
Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status.
Sliwinska A, Sitarek P, Toma M, Czarny P, Synowiec E, Krupa R, Wigner P, Bialek K, Kwiatkowski D, Korycinska A, Majsterek I, Szemraj J, Galecki P, Sliwinski T. Sliwinska A, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):311-316. doi: 10.1016/j.pnpbp.2017.07.010. Epub 2017 Jul 11. Prog Neuropsychopharmacol Biol Psychiatry. 2017. PMID: 28710029
BACKGROUND: Neurodegeneration in Alzheimer's disease can be caused by accumulation of oxidative DNA damage resulting from altered expression of genes involved in the base excision repair system (BER). Promoter methylation can affect the profile of BER gene …
BACKGROUND: Neurodegeneration in Alzheimer's disease can be caused by accumulation of oxidative DNA damage resulting from altered expression …
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Mengwasser KE, et al. Mol Cell. 2019 Mar 7;73(5):885-899.e6. doi: 10.1016/j.molcel.2018.12.008. Epub 2019 Jan 24. Mol Cell. 2019. PMID: 30686591 Free PMC article.
We found that BRCA2-deficient cells are selectively dependent on multiple pathways including base excision repair, ATR signaling, and splicing. We identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function. BRCA2-deficient cells require …
We found that BRCA2-deficient cells are selectively dependent on multiple pathways including base excision repair, ATR signaling, and splici …
Reporter Assays for BER Pathway.
Piekna-Przybylska D. Piekna-Przybylska D. Methods Mol Biol. 2019;1999:145-160. doi: 10.1007/978-1-4939-9500-4_8. Methods Mol Biol. 2019. PMID: 31127574
In addition, BER mechanisms can be affected by viral infections, such as HPV, HTLV-1, and HIV-1. ...In this chapter, we describe this plasmid-based reporter gene system to investigate in cell the repairs of DNA damages involving BER mechanisms....
In addition, BER mechanisms can be affected by viral infections, such as HPV, HTLV-1, and HIV-1. ...In this chapter, we describe this …
Base Excision Repair: Mechanisms and Impact in Biology, Disease, and Medicine.
Gohil D, Sarker AH, Roy R. Gohil D, et al. Int J Mol Sci. 2023 Sep 16;24(18):14186. doi: 10.3390/ijms241814186. Int J Mol Sci. 2023. PMID: 37762489 Free PMC article. Review.
Since its discovery in 1974, the field has grown in several facets: mechanisms, biology and physiology, understanding deficiencies and human disease, and using BER genes as potential inhibitory targets to develop therapeutics. Within its segregation of short nucleot …
Since its discovery in 1974, the field has grown in several facets: mechanisms, biology and physiology, understanding deficiencies and human …
Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity.
Patrono C, Sterpone S, Testa A, Cozzi R. Patrono C, et al. World J Clin Oncol. 2014 Dec 10;5(5):874-82. doi: 10.5306/wjco.v5.i5.874. World J Clin Oncol. 2014. PMID: 25493225 Free PMC article. Review.
Here, we review the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1 (XRCC1), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyr …
Here, we review the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on …
Polymorphisms in genes implicated in base excision repair (BER) pathway are associated with susceptibility to Paget's disease of bone.
Usategui-Martín R, Gutiérrez-Cerrajero C, Jiménez-Vázquez S, Calero-Paniagua I, García-Aparicio J, Corral-Gudino L, Del Pino-Montes J, González-Sarmiento R. Usategui-Martín R, et al. Bone. 2018 Jul;112:19-23. doi: 10.1016/j.bone.2018.04.003. Epub 2018 Apr 7. Bone. 2018. PMID: 29630930
Therefore, our hypothesis is that defective response to DNA damage may lead to somatic mutations favouring an increased risk of PDB. So that we have analysed polymorphisms in DNA repair genes involved in the BER, NER and DSBR pathways in order to evaluate the role o …
Therefore, our hypothesis is that defective response to DNA damage may lead to somatic mutations favouring an increased risk of PDB. So that …
Base excision repair capacity in informing healthspan.
Brenerman BM, Illuzzi JL, Wilson DM 3rd. Brenerman BM, et al. Carcinogenesis. 2014 Dec;35(12):2643-52. doi: 10.1093/carcin/bgu225. Epub 2014 Oct 29. Carcinogenesis. 2014. PMID: 25355293 Free PMC article. Review.
In humans, measurement of BER variation has been imperfect to this point, yet tools to assess BER in epidemiological surveys are steadily evolving. We provide herein an overview of the BER pathway and discuss the current efforts toward defining the relationsh …
In humans, measurement of BER variation has been imperfect to this point, yet tools to assess BER in epidemiological surveys a …
966 results