Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A.
Pein H, et al.
Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5.
Nat Commun. 2018.
PMID: 30237488
Free PMC article.
Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human vitamin E metabolites, that long-chain omega-carboxylates are potent allosteric inhibitors of 5-l …
Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by l …