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Page 1
Overcoming the delivery problem for therapeutic genome editing: Current status and perspective of non-viral methods.
Mashel TV, Tarakanchikova YV, Muslimov AR, Zyuzin MV, Timin AS, Lepik KV, Fehse B. Mashel TV, et al. Biomaterials. 2020 Nov;258:120282. doi: 10.1016/j.biomaterials.2020.120282. Epub 2020 Aug 6. Biomaterials. 2020. PMID: 32798742 Review.
Whereas significant progress has been made in ex vivo GE delivery (e.g., by electroporation), establishment of efficient and safe in vivo delivery systems is still a challenge. ...
Whereas significant progress has been made in ex vivo GE delivery (e.g., by electroporation), establishment of efficient and safe in …
Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.
Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S. Kudrnac M, et al. J Biol Chem. 2009 May 1;284(18):12276-84. doi: 10.1074/jbc.M808402200. Epub 2009 Mar 5. J Biol Chem. 2009. PMID: 19265197 Free PMC article.
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), where S6 segments are likely to seal the channel in the closed conformation (Hohaus, A., Beyl, S., Kudrnac, M., Berjukow, S., Timin, …
Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), …
Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma.
Rogova A, Gorbunova IA, Karpov TE, Sidorov RY, Rubtsov AE, Shipilovskikh DA, Muslimov AR, Zyuzin MV, Timin AS, Shipilovskikh SA. Rogova A, et al. Eur J Med Chem. 2023 Jun 5;254:115325. doi: 10.1016/j.ejmech.2023.115325. Epub 2023 Apr 13. Eur J Med Chem. 2023. PMID: 37084598
The design and synthesis of new promising compounds based on thienopyrimidine scaffold containing 2-aminothiophene fragments with good safety and favorable drug-like properties are highly relevant for chemotherapy. In this study, a series of 14 variants of thieno[3,2-e]pyr …
The design and synthesis of new promising compounds based on thienopyrimidine scaffold containing 2-aminothiophene fragments with good safet …
Recent Advances of Individual BODIPY and BODIPY-Based Functional Materials in Medical Diagnostics and Treatment.
Marfin YS, Solomonov AV, Timin AS, Rumyantsev EV. Marfin YS, et al. Curr Med Chem. 2017;24(25):2745-2772. doi: 10.2174/0929867324666170601092327. Curr Med Chem. 2017. PMID: 28571557 Review.
RESULTS: The present review focuses on the recent advances for application of individual BODIPY in medical diagnostics, antimicrobial activity, as well as establishing the role of BODIPY in labeling of biomolecules (e.g. proteins, hormones and DNA). Also the review highlig …
RESULTS: The present review focuses on the recent advances for application of individual BODIPY in medical diagnostics, antimicrobial activi …
Porous Inorganic Carriers Based on Silica, Calcium Carbonate and Calcium Phosphate for Controlled/Modulated Drug Delivery: Fresh Outlook and Future Perspectives.
Trofimov AD, Ivanova AA, Zyuzin MV, Timin AS. Trofimov AD, et al. Pharmaceutics. 2018 Sep 25;10(4):167. doi: 10.3390/pharmaceutics10040167. Pharmaceutics. 2018. PMID: 30257514 Free PMC article. Review.
Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic field, and ultrasound). ...
Special focus is dedicated to the loading capacity, controllable release of drugs under internal biological stimuli (e.g., pH, redox, …
Sm/Co-Doped Silica-Based Nanozymes Reprogram Tumor Microenvironment for ATP-Inhibited Tumor Therapy.
Li S, Ding H, Chang J, Liu S, Dong S, Zyuzin MV, Timin AS, Feng L, He F, Gai S, Yang P. Li S, et al. Adv Healthc Mater. 2023 Sep;12(24):e2300652. doi: 10.1002/adhm.202300652. Epub 2023 Jun 20. Adv Healthc Mater. 2023. PMID: 37306377
Herein, the Sm/Co-doped mesoporous silica with 3PO-loaded nanozymes (denoted as mSC-3PO) are rationally constructed for simultaneously inhibiting energy production by adenosine triphosphate (ATP) inhibitor 3PO and reprogramming TME by multiactivities of nanozymes with phototherma …
Herein, the Sm/Co-doped mesoporous silica with 3PO-loaded nanozymes (denoted as mSC-3PO) are rationally constructed for simultaneously inhib …
Examining PM2.5 concentrations and exposure using multiple models.
Kelly JT, Jang C, Timin B, Di Q, Schwartz J, Liu Y, van Donkelaar A, Martin RV, Berrocal V, Bell ML. Kelly JT, et al. Environ Res. 2021 May;196:110432. doi: 10.1016/j.envres.2020.110432. Epub 2020 Nov 7. Environ Res. 2021. PMID: 33166538 Free PMC article.
Epidemiologic studies have found associations between fine particulate matter (PM(2.5)) exposure and adverse health effects using exposure models that incorporate monitoring data and other relevant information. Here, we use nine PM(2.5) concentration models (i.e., exposure …
Epidemiologic studies have found associations between fine particulate matter (PM(2.5)) exposure and adverse health effects using exposure m …
Impact of metallic coating on the retention of 225Ac and its daugthers within core-shell nanocarriers.
Karpov TE, Muslimov AR, Antuganov DO, Postovalova AS, Pavlov DA, Usov YV, Shatik SV, Zyuzin MV, Timin AS. Karpov TE, et al. J Colloid Interface Sci. 2022 Feb 15;608(Pt 3):2571-2583. doi: 10.1016/j.jcis.2021.10.187. Epub 2021 Nov 2. J Colloid Interface Sci. 2022. PMID: 34801240
At the same time, almost no accumulation of leaked radionuclides can be detected in non-target organs (e.g., in the kidneys). In contrast, non-modified carriers (SiO(2) NPs) demonstrate the release of free radionuclides, which are distributed over the whole animal body wit …
At the same time, almost no accumulation of leaked radionuclides can be detected in non-target organs (e.g., in the kidneys). In cont …
Laser-Assisted Design of MOF-Derivative Platforms from Nano- to Centimeter Scales for Photonic and Catalytic Applications.
Gunina EV, Zhestkij NA, Sergeev M, Bachinin SV, Mezenov YA, Kulachenkov NK, Timofeeva M, Ivashchenko V, Timin AS, Shipilovskikh SA, Yakubova AA, Pavlov DI, Potapov AS, Gong J, Khamkhash L, Atabaev TS, Bruyere S, Milichko VA. Gunina EV, et al. ACS Appl Mater Interfaces. 2023 Oct 11;15(40):47541-47551. doi: 10.1021/acsami.3c10193. Epub 2023 Sep 29. ACS Appl Mater Interfaces. 2023. PMID: 37773641
Five three- and two-dimensional MOFs, differing in chemical composition, topology, and thermal resistance, have been selected as precursors. Tuning the laser parameters (i.e., pulse duration from fs to ns and repetition rate from kHz to MHz), we switch between ultrafast no …
Five three- and two-dimensional MOFs, differing in chemical composition, topology, and thermal resistance, have been selected as precursors. …
19 results