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Page 1
Models for oral uptake of nanoparticles in consumer products.
Fröhlich E, Roblegg E. Fröhlich E, et al. Toxicology. 2012 Jan 27;291(1-3):10-7. doi: 10.1016/j.tox.2011.11.004. Epub 2011 Nov 18. Toxicology. 2012. PMID: 22120540 Free PMC article. Review.
Presently, many consumer products contain nano-sized materials (NMs) to improve material properties, product quality and ease of use. NMs in food additives and in cosmetic articles (e.g., tooth paste) may be taken up by the oral route. As adverse effects of environmental n …
Presently, many consumer products contain nano-sized materials (NMs) to improve material properties, product quality and ease of use. NMs in …
NANEX: Process design and optimization.
Baumgartner R, Matić J, Schrank S, Laske S, Khinast J, Roblegg E. Baumgartner R, et al. Int J Pharm. 2016 Jun 15;506(1-2):35-45. doi: 10.1016/j.ijpharm.2016.04.029. Epub 2016 Apr 14. Int J Pharm. 2016. PMID: 27090153
To this end, we investigated four polymers with different physicochemical characteristics (Kollidon() VA64, Eudragit() E PO, HPMCAS and PEG 20000) in terms of their maximum water uptake/removal capacity. ...
To this end, we investigated four polymers with different physicochemical characteristics (Kollidon() VA64, Eudragit() E PO, HPMCAS a …
A comprehensive overview of advanced dynamic in vitro intestinal and hepatic cell culture models.
Leal F, Zeiringer S, Jeitler R, Costa PF, Roblegg E. Leal F, et al. Tissue Barriers. 2024 Jan 2;12(1):2163820. doi: 10.1080/21688370.2022.2163820. Epub 2023 Jan 21. Tissue Barriers. 2024. PMID: 36680530 Free PMC article. Review.
Herein, current microfluidic in vitro intestinal and hepatic models are reviewed, namely single- and multi-tissue micro-bioreactors, which are associated with different methods of cell cultivation, i.e., scaffold-based versus scaffold-free....
Herein, current microfluidic in vitro intestinal and hepatic models are reviewed, namely single- and multi-tissue micro-bioreactors, which a …
Development of a Workflow to Engineer Tailored Microparticles Via Inkjet Printing.
Winter C, Zettl M, Mantanus J, Hadjittofis E, Leitinger G, Kolb D, Hsiao WK, Spoerk M, Paudel A, Roblegg E, Pinto JT. Winter C, et al. Pharm Res. 2023 Jan;40(1):281-294. doi: 10.1007/s11095-022-03426-4. Epub 2022 Nov 15. Pharm Res. 2023. PMID: 36380170
The addition of pore former and polymer allowed to tailor the crystallization kinetics, resulting in particles with a different surface (i.e., spike-like surface) and bulk (e.g. porous and non-porous) structure. ...
The addition of pore former and polymer allowed to tailor the crystallization kinetics, resulting in particles with a different surface (i. …
Toward a new generation of vaginal pessaries via 3D-printing: Concomitant mechanical support and drug delivery.
Eder S, Wiltschko L, Koutsamanis I, Afonso Urich JA, Arbeiter F, Roblegg E, Spoerk M. Eder S, et al. Eur J Pharm Biopharm. 2022 May;174:77-89. doi: 10.1016/j.ejpb.2022.04.001. Epub 2022 Apr 4. Eur J Pharm Biopharm. 2022. PMID: 35390451
To improve patient adherence, vaginal pessaries - polymeric structures providing mechanical support to treat stress urinary incontinence (SUI) - greatly benefit from 3D-printing through customization of their mechanics, e.g. infill modifications. However, currently only li …
To improve patient adherence, vaginal pessaries - polymeric structures providing mechanical support to treat stress urinary incontinence (SU …
Needles to Spheres: Evaluation of inkjet printing as a particle shape enhancement tool.
Zettl M, Winter C, Mantanus J, Hadjittofis E, Rome S, Leitinger G, Hsiao WK, Roblegg E, Pinto JT, Spoerk M. Zettl M, et al. Eur J Pharm Biopharm. 2023 Mar;184:92-102. doi: 10.1016/j.ejpb.2023.01.016. Epub 2023 Jan 25. Eur J Pharm Biopharm. 2023. PMID: 36707008
Active pharmaceutical ingredients (APIs) often reveal shapes challenging to process, e.g. acicular structures, and exhibit reduced bioavailability induced by slow dissolution rate. ...
Active pharmaceutical ingredients (APIs) often reveal shapes challenging to process, e.g. acicular structures, and exhibit reduced bi …
Development and Characterization of an In Vitro Intestinal Model Including Extracellular Matrix and Macrovascular Endothelium.
Zeiringer S, Wiltschko L, Glader C, Reiser M, Absenger-Novak M, Fröhlich E, Roblegg E. Zeiringer S, et al. Mol Pharm. 2023 Oct 2;20(10):5173-5184. doi: 10.1021/acs.molpharmaceut.3c00532. Epub 2023 Sep 7. Mol Pharm. 2023. PMID: 37677739 Free PMC article.
They usually consist of enterocytes and mucus-producing cells cultured for 3 weeks, e.g., on Transwells, to obtain a fully differentiated cell layer simulating the human epithelium. ...Drug tests led to ex vivo comparable permeability coefficients (P(app)) (i.e., P( …
They usually consist of enterocytes and mucus-producing cells cultured for 3 weeks, e.g., on Transwells, to obtain a fully differenti …
Comprehensive investigation of saliva replacement liquids for the treatment of xerostomia.
Spirk C, Hartl S, Pritz E, Gugatschka M, Kolb-Lenz D, Leitinger G, Roblegg E. Spirk C, et al. Int J Pharm. 2019 Nov 25;571:118759. doi: 10.1016/j.ijpharm.2019.118759. Epub 2019 Oct 14. Int J Pharm. 2019. PMID: 31622744
The latter have been reported to be ineffective as special physicochemical features of natural saliva have so far been ignored (e.g., buffer capacity, osmolality, etc.). The aim of this study was to comprehensively investigate the most relevant physicochemical properties o …
The latter have been reported to be ineffective as special physicochemical features of natural saliva have so far been ignored (e.g., …
The buccal mucosa as a route for TiO2 nanoparticle uptake.
Teubl BJ, Leitinger G, Schneider M, Lehr CM, Fröhlich E, Zimmer A, Roblegg E. Teubl BJ, et al. Nanotoxicology. 2015 Mar;9(2):253-61. doi: 10.3109/17435390.2014.921343. Epub 2014 May 29. Nanotoxicology. 2015. PMID: 24873758
In this study, interactions of three distinct titanium dioxide (TiO2) particles (i.e. NM 100, NM 101 and NM 105) with oral tissues are presented. ...
In this study, interactions of three distinct titanium dioxide (TiO2) particles (i.e. NM 100, NM 101 and NM 105) with oral tissues ar …
In-vitro permeability of neutral polystyrene particles via buccal mucosa.
Teubl BJ, Meindl C, Eitzlmayr A, Zimmer A, Fröhlich E, Roblegg E. Teubl BJ, et al. Small. 2013 Feb 11;9(3):457-66. doi: 10.1002/smll.201201789. Epub 2012 Oct 30. Small. 2013. PMID: 23112142
Compared to 25 and 50 nm particles, 200 nm PP particles penetrate into deeper regions of the mucosa. This is attributed to the structure of the buccal mucosa, i.e., mucus layer and microplicae. The particles permeate the mucus layer and deposit in ridge-like folds of super …
Compared to 25 and 50 nm particles, 200 nm PP particles penetrate into deeper regions of the mucosa. This is attributed to the structure of …
22 results