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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1952 1
1963 1
1966 1
1967 3
1976 1
1983 2
1986 1
1988 2
1990 5
1991 9
1992 5
1993 3
1994 8
1995 8
1996 15
1997 14
1998 13
1999 11
2000 15
2001 16
2002 24
2003 35
2004 28
2005 37
2006 47
2007 56
2008 54
2009 67
2010 56
2011 51
2012 61
2013 76
2014 150
2015 220
2016 254
2017 291
2018 315
2019 323
2020 363
2021 405
2022 370
2023 347
2024 109

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3,472 results

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Page 1
Vitamin E-Conjugated Phosphopeptide Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1.
Yim MS, Soung NK, Han EH, Min JY, Han H, Son EJ, Kim HN, Kim B, Bang JK, Ryu EK. Yim MS, et al. Mol Pharm. 2019 Dec 2;16(12):4867-4877. doi: 10.1021/acs.molpharmaceut.9b00757. Epub 2019 Nov 11. Mol Pharm. 2019. PMID: 31663746
Polo-like kinase 1 (Plk1) regulates cell cycle and cell proliferation, and is currently considered a potential biomarker in clinical trials for many cancers. A characteristic feature of Plks is their C-terminal polo-box domain (PBD). Pro-Leu-His-Ser-pThr (PLHS[pT])- …
Polo-like kinase 1 (Plk1) regulates cell cycle and cell proliferation, and is currently considered a potential biomarker in clinical …
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1).
Luo P, Yan H, Du J, Chen X, Shao J, Zhang Y, Xu Z, Jin Y, Lin N, Yang B, He Q. Luo P, et al. Autophagy. 2021 Oct;17(10):3221-3237. doi: 10.1080/15548627.2020.1851492. Epub 2020 Dec 14. Autophagy. 2021. PMID: 33315519 Free PMC article.
Notably, this autophagy-promoted apoptosis is dependent on PLK1 (polo like kinase 1). Both AAV8-mediated Plk1 knockdown and PLK1 inhibitor BI-2536 could mitigate the gefitinib-induced hepatotoxicity in vivo by abrogating the autophagic degradation of the COX6A1 protein. .. …
Notably, this autophagy-promoted apoptosis is dependent on PLK1 (polo like kinase 1). Both AAV8-mediated Plk1 knockdown and PLK1 inhi …
Food Microbiology.
Laranjo M, Córdoba MG, Semedo-Lemsaddek T, Potes ME. Laranjo M, et al. Biomed Res Int. 2019 Apr 4;2019:8039138. doi: 10.1155/2019/8039138. eCollection 2019. Biomed Res Int. 2019. PMID: 31080829 Free PMC article. No abstract available.
Plant-Pathogen Interaction.
Campos MD, Patanita M, Varanda C, Materatski P, Félix MDR. Campos MD, et al. Biology (Basel). 2021 May 19;10(5):444. doi: 10.3390/biology10050444. Biology (Basel). 2021. PMID: 34069323 Free PMC article.
When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.
Niño CA, Sala S, Polo S. Niño CA, et al. Semin Cell Dev Biol. 2019 Sep;93:136-144. doi: 10.1016/j.semcdb.2018.12.005. Epub 2018 Dec 20. Semin Cell Dev Biol. 2019. PMID: 30566893 Review.
As such, de-regulation of E-cadherin has deleterious effects on cells and whole tissues. ...Importantly, the turnover of E-cadherin is required for both cell adhesion and cell plasticity within a tissue. ...
As such, de-regulation of E-cadherin has deleterious effects on cells and whole tissues. ...Importantly, the turnover of E-cad …
Therapeutic potential of targeting polo-like kinase 4.
Lei Q, Yu Q, Yang N, Xiao Z, Song C, Zhang R, Yang S, Liu Z, Deng H. Lei Q, et al. Eur J Med Chem. 2024 Feb 5;265:116115. doi: 10.1016/j.ejmech.2023.116115. Epub 2024 Jan 3. Eur J Med Chem. 2024. PMID: 38199166 Review.
Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully regulates centriole duplication in a spatiotemporal manner to ensure the fidelity of centrosome duplication and proper mitosis. ...As such, numerous small-molecule inhibitors with distinct c …
Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully regulates centriole duplication in a spatiotempora …
Editorial-Current Insights on Lipid-Based Nanosystems.
Silva AC, Moreira JN, Lobo JMS. Silva AC, et al. Pharmaceuticals (Basel). 2022 Oct 14;15(10):1267. doi: 10.3390/ph15101267. Pharmaceuticals (Basel). 2022. PMID: 36297379 Free PMC article.
When the Words Serve As Drugs.
Mistraletti G, Giannini A. Mistraletti G, et al. Chest. 2021 Jun;159(6):2137-2138. doi: 10.1016/j.chest.2021.02.061. Chest. 2021. PMID: 34099119 No abstract available.
3,472 results