Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.
Sebastiani F, Yanez Arteta M, Lerche M, Porcar L, Lang C, Bragg RA, Elmore CS, Krishnamurthy VR, Russell RA, Darwish T, Pichler H, Waldie S, Moulin M, Haertlein M, Forsyth VT, Lindfors L, Cárdenas M.
Sebastiani F, et al.
ACS Nano. 2021 Apr 27;15(4):6709-6722. doi: 10.1021/acsnano.0c10064. Epub 2021 Mar 23.
ACS Nano. 2021.
PMID: 33754708
Free PMC article.
The biodistribution and cellular uptake of LNPs are affected by their surface composition as well as by the extracellular proteins present at the site of LNP administration, e.g., apolipoproteinE (ApoE). ApoE, being responsible for fat transport in the body, plays a key ro …
The biodistribution and cellular uptake of LNPs are affected by their surface composition as well as by the extracellular proteins present a …