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In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm.
Ruterbusch M, Pruner KB, Shehata L, Pepper M. Ruterbusch M, et al. Annu Rev Immunol. 2020 Apr 26;38:705-725. doi: 10.1146/annurev-immunol-103019-085803. Annu Rev Immunol. 2020. PMID: 32340571 Review.
Cytokine production by antigen-presenting cells and other innate cells influences the CD4(+) T cell effector program [e.g., T helper type 1 (Th1), Th2, Th17]. Signals downstream of the T cell receptor influence whether individual clones bearing hallmarks of this eff …
Cytokine production by antigen-presenting cells and other innate cells influences the CD4(+) T cell effector program [e.g., T …
Dexamethasone in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.
Transfusion thresholds for guiding red blood cell transfusion.
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC. Carson JL, et al. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. Cochrane Database Syst Rev. 2021. PMID: 34932836 Free PMC article. Review.
The restrictive transfusion threshold uses a lower haemoglobin concentration as a threshold for transfusion (most commonly, 7.0 g/dL to 8.0 g/dL), and the liberal transfusion threshold uses a higher haemoglobin concentration as a threshold for transfusion (most comm …
The restrictive transfusion threshold uses a lower haemoglobin concentration as a threshold for transfusion (most commonly, 7.0 g/dL …
Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression.
Reif A, Bitter I, Buyze J, Cebulla K, Frey R, Fu DJ, Ito T, Kambarov Y, Llorca PM, Oliveira-Maia AJ, Messer T, Mulhern-Haughey S, Rive B, von Holt C, Young AH, Godinov Y; ESCAPE-TRD Investigators. Reif A, et al. N Engl J Med. 2023 Oct 5;389(14):1298-1309. doi: 10.1056/NEJMoa2304145. N Engl J Med. 2023. PMID: 37792613 Clinical Trial.
All patients were included in the analysis; patients who discontinued the trial treatment were considered as having had an unfavorable outcome (i.e., they were grouped with patients who did not have remission or who had a relapse). ...
All patients were included in the analysis; patients who discontinued the trial treatment were considered as having had an unfavorable outco …
A Dual-Chamber Leadless Pacemaker.
Knops RE, Reddy VY, Ip JE, Doshi R, Exner DV, Defaye P, Canby R, Bongiorni MG, Shoda M, Hindricks G, Neužil P, Rashtian M, Breeman KTN, Nevo JR, Ganz L, Hubbard C, Cantillon DJ; Aveir DR i2i Study Investigators. Knops RE, et al. N Engl J Med. 2023 Jun 22;388(25):2360-2370. doi: 10.1056/NEJMoa2300080. Epub 2023 May 20. N Engl J Med. 2023. PMID: 37212442
The primary safety end point was freedom from complications (i.e., device- or procedure-related serious adverse events) at 90 days. ...RESULTS: Among the 300 patients enrolled, 190 (63.3%) had sinus-node dysfunction and 100 (33.3%) had atrioventricular block as the primary …
The primary safety end point was freedom from complications (i.e., device- or procedure-related serious adverse events) at 90 days. . …
Omitting Radiotherapy after Breast-Conserving Surgery in Luminal A Breast Cancer.
Whelan TJ, Smith S, Parpia S, Fyles AW, Bane A, Liu FF, Rakovitch E, Chang L, Stevens C, Bowen J, Provencher S, Théberge V, Mulligan AM, Kos Z, Akra MA, Voduc KD, Hijal T, Dayes IS, Pond G, Wright JR, Nielsen TO, Levine MN; LUMINA Study Investigators. Whelan TJ, et al. N Engl J Med. 2023 Aug 17;389(7):612-619. doi: 10.1056/NEJMoa2302344. N Engl J Med. 2023. PMID: 37585627
Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines.
Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, Fergusson D, Arbous S, Bauer SR, China L, Fung M, Jug R, Neill M, Paine C, Pavenski K, Shah PS, Robinson S, Shan H, Szczepiorkowski ZM, Thevenot T, Wu B, Stanworth S, Shehata N; International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group. Callum J, et al. Chest. 2024 Mar 4:S0012-3692(24)00285-X. doi: 10.1016/j.chest.2024.02.049. Online ahead of print. Chest. 2024. PMID: 38447639 Free article.
Effect of Donor Sex on Recipient Mortality in Transfusion.
Chassé M, Fergusson DA, Tinmouth A, Acker JP, Perelman I, Tuttle A, English SW, Hawken S, Forster AJ, Shehata N, Thavorn K, Wilson K, Cober N, Maddison H, Tokessy M. Chassé M, et al. N Engl J Med. 2023 Apr 13;388(15):1386-1395. doi: 10.1056/NEJMoa2211523. N Engl J Med. 2023. PMID: 37043654 Clinical Trial.
The baseline hemoglobin level before transfusion was 79.519.7 g per liter, and patients received a mean of 5.410.5 units of red cells in the female donor group and 5.18.9 units in the male donor group (difference, 0.3 units; 95% confidence interval [CI], -0.1 to 0.7). ...
The baseline hemoglobin level before transfusion was 79.519.7 g per liter, and patients received a mean of 5.410.5 units of red cells …
Regional Nodal Irradiation in Early-Stage Breast Cancer.
Whelan TJ, Olivotto IA, Parulekar WR, Ackerman I, Chua BH, Nabid A, Vallis KA, White JR, Rousseau P, Fortin A, Pierce LJ, Manchul L, Chafe S, Nolan MC, Craighead P, Bowen J, McCready DR, Pritchard KI, Gelmon K, Murray Y, Chapman JA, Chen BE, Levine MN; MA.20 Study Investigators. Whelan TJ, et al. N Engl J Med. 2015 Jul 23;373(4):307-16. doi: 10.1056/NEJMoa1415340. N Engl J Med. 2015. PMID: 26200977 Free PMC article. Clinical Trial.
Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk.
Shehata SA, Toraih EA, Ismail EA, Hagras AM, Elmorsy E, Fawzy MS. Shehata SA, et al. Cancers (Basel). 2023 Sep 12;15(18):4525. doi: 10.3390/cancers15184525. Cancers (Basel). 2023. PMID: 37760496 Free PMC article. Review.
Genetic, lifestyle, and environmental exposure play an important role as risk factors for LC. E-cigarette, or vaping, products (EVPs) use has been dramatically increasing world-wide. ...However, the relationship between EVPs and LC is not well established. E-cigaret …
Genetic, lifestyle, and environmental exposure play an important role as risk factors for LC. E-cigarette, or vaping, products (EVPs) …
65 results