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2001 1
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2020 4
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Page 1
Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD.
Rabe KF, Martinez FJ, Ferguson GT, Wang C, Singh D, Wedzicha JA, Trivedi R, St Rose E, Ballal S, McLaren J, Darken P, Aurivillius M, Reisner C, Dorinsky P; ETHOS Investigators. Rabe KF, et al. N Engl J Med. 2020 Jul 2;383(1):35-48. doi: 10.1056/NEJMoa1916046. Epub 2020 Jun 24. N Engl J Med. 2020. PMID: 32579807 Clinical Trial.
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
The impact of lung ultrasound on clinical-decision making across departments: a systematic review.
Heldeweg MLA, Vermue L, Kant M, Brouwer M, Girbes ARJ, Haaksma ME, Heunks LMA, Mousa A, Smit JM, Smits TW, Paulus F, Ket JCF, Schultz MJ, Tuinman PR. Heldeweg MLA, et al. Ultrasound J. 2022 Jan 10;14(1):5. doi: 10.1186/s13089-021-00253-3. Ultrasound J. 2022. PMID: 35006383 Free PMC article. Review.
PubMed, EMBASE, and Web of Science were searched for original studies reporting changes in clinical-decision making (e.g. diagnosis, management, or therapy) after using lung ultrasound. ...
PubMed, EMBASE, and Web of Science were searched for original studies reporting changes in clinical-decision making (e.g. diagnosis, …
Lung ultrasound findings in patients with novel SARS-CoV-2.
Haaksma ME, Heldeweg MLA, Lopez Matta JE, Smit JM, van Trigt JD, Nooitgedacht JS, Elzo Kraemer CV, van de Wiel M, Girbes ARJ, Heunks L, van Westerloo DJ, Tuinman PR. Haaksma ME, et al. ERJ Open Res. 2020 Nov 16;6(4):00238-2020. doi: 10.1183/23120541.00238-2020. eCollection 2020 Oct. ERJ Open Res. 2020. PMID: 33257915 Free PMC article.
Activities for Residents of Dutch Nursing Homes during the COVID-19 Pandemic: A Qualitative Study.
Smeitink MMP, Smaling HJA, van Tol LS, Haaksma ML, Caljouw MAA, Achterberg WP. Smeitink MMP, et al. Int J Environ Res Public Health. 2022 Apr 30;19(9):5465. doi: 10.3390/ijerph19095465. Int J Environ Res Public Health. 2022. PMID: 35564860 Free PMC article.
Activities were offered in an adapted way, often under certain conditions, such as organizing activities at other locations (e.g., outside), with limited group size, and following specific guidelines. ...
Activities were offered in an adapted way, often under certain conditions, such as organizing activities at other locations (e.g., ou …
Survival time tool to guide care planning in people with dementia.
Haaksma ML, Eriksdotter M, Rizzuto D, Leoutsakos JS, Olde Rikkert MGM, Melis RJF, Garcia-Ptacek S. Haaksma ML, et al. Neurology. 2020 Feb 4;94(5):e538-e548. doi: 10.1212/WNL.0000000000008745. Epub 2019 Dec 16. Neurology. 2020. PMID: 31843808 Free PMC article.
METHODS: We conducted a nationwide registry-linkage study including 829 health centers, i.e., all memory clinics and 75% of primary care facilities, across Sweden. ...
METHODS: We conducted a nationwide registry-linkage study including 829 health centers, i.e., all memory clinics and 75% of primary c …
Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
Engelhardt H, de Esch IJ, Kuhn D, Smits RA, Zuiderveld OP, Dobler J, Mayer M, Lips S, Arnhof H, Scharn D, Haaksma EE, Leurs R. Engelhardt H, et al. Eur J Med Chem. 2012 Aug;54:660-8. doi: 10.1016/j.ejmech.2012.06.016. Epub 2012 Jun 18. Eur J Med Chem. 2012. PMID: 22749391
These properties qualify these compounds as a possible new standard for future in vivo studies (e.g 51, 52 and 55). Moreover, the current studies also provide valuable information on the potential receptor ligand interactions between the indolcarboxamides and the H(4)R pro …
These properties qualify these compounds as a possible new standard for future in vivo studies (e.g 51, 52 and 55). Moreover, the cur …
Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.
Engelhardt H, Schultes S, de Graaf C, Nijmeijer S, Vischer HF, Zuiderveld OP, Dobler J, Stachurski K, Mayer M, Arnhof H, Scharn D, Haaksma EE, de Esch IJ, Leurs R. Engelhardt H, et al. J Med Chem. 2013 Jun 13;56(11):4264-76. doi: 10.1021/jm301886t. Epub 2013 May 28. J Med Chem. 2013. PMID: 23668417
This moiety is however also the metabolic hot spot for various classes of H4R ligands (e.g., indolcarboxamides and pyrimidines). We set out to investigate whether mildly basic 2-aminopyrimidines in combination with the appropriate linker can serve as a replacement for the …
This moiety is however also the metabolic hot spot for various classes of H4R ligands (e.g., indolcarboxamides and pyrimidines). We s …
Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.
Jongejan A, Lim HD, Smits RA, de Esch IJ, Haaksma E, Leurs R. Jongejan A, et al. J Chem Inf Model. 2008 Jul;48(7):1455-63. doi: 10.1021/ci700474a. Epub 2008 Jun 14. J Chem Inf Model. 2008. PMID: 18553960
A three-dimensional homology model of the human histamine H 4 receptor was developed to investigate the binding mode of a series of structurally diverse H 4-agonists, i.e. histamine, clozapine, and the recently described selective, nonimidazole agonist VUF 8430. Mutagenesi …
A three-dimensional homology model of the human histamine H 4 receptor was developed to investigate the binding mode of a series of structur …
11 results